| pubmed-article:9364048 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0376604 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0521428 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0015283 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0034107 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0442711 | lld:lifeskim |
| pubmed-article:9364048 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:9364048 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:9364048 | pubmed:dateCreated | 1997-12-15 | lld:pubmed |
| pubmed-article:9364048 | pubmed:abstractText | Stimulus-secretion coupling was monitored with capacitance detection in bovine chromaffin cells recorded in perforated patch mode and stimulated with trains of depolarizing pulses. A subset of stimulus trains evoked a response with a Ca2+-exocytosis relationship identical to that obtained for single depolarizing pulses (Engisch and Nowycky, 1996). Other trains evoked responses with enhanced or diminished Ca2+ efficacy relative to this input-output function. The probability of obtaining a particular Ca2+-exocytosis relationship was correlated with the amount of Ca2+ entry per pulse, such that shorter pulses or smaller currents were associated with the greatest efficacy, and longer pulses and larger currents with the lowest efficacy. Apparent enhancements in Ca2+ efficacy were not caused by residual Ca2+ summing between pulses, because decreasing the interval between pulses usually reduced efficacy in the same cell; conversely, increasing the interval between pulses did not prevent an enhanced Ca2+-exocytosis relationship. Apparent decreases in Ca2+ efficacy were not caused by depletion of an available pool of release-ready vesicles, because an equivalent amount of total Ca2+ entry during a single long depolarizing pulse usually evoked a much larger secretory response in the same cell. Finally, there were no striking differences in global Ca2+ levels monitored with the fluorescent indicator Fura Red that could account for apparent changes in Ca2+ efficacy during repetitive stimulus protocols. It appears that in chromaffin cells, the Ca2+-exocytosis relationship is subject to activity-dependent changes during a stimulus train and can be modulated up or down from a basal state accessed by single pulse stimulations. | lld:pubmed |
| pubmed-article:9364048 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9364048 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9364048 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9364048 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9364048 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9364048 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9364048 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9364048 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:9364048 | pubmed:author | pubmed-author:NowyckyM CMC | lld:pubmed |
| pubmed-article:9364048 | pubmed:author | pubmed-author:EngischK LKL | lld:pubmed |
| pubmed-article:9364048 | pubmed:author | pubmed-author:ChernevskayaN... | lld:pubmed |
| pubmed-article:9364048 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9364048 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9364048 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9364048 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9364048 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9364048 | pubmed:pagination | 9010-25 | lld:pubmed |
| pubmed-article:9364048 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9364048 | pubmed:meshHeading | pubmed-meshheading:9364048-... | lld:pubmed |
| pubmed-article:9364048 | pubmed:meshHeading | pubmed-meshheading:9364048-... | lld:pubmed |
| pubmed-article:9364048 | pubmed:meshHeading | pubmed-meshheading:9364048-... | lld:pubmed |
| pubmed-article:9364048 | pubmed:meshHeading | pubmed-meshheading:9364048-... | lld:pubmed |
| pubmed-article:9364048 | pubmed:meshHeading | pubmed-meshheading:9364048-... | lld:pubmed |
| pubmed-article:9364048 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9364048 | pubmed:articleTitle | Short-term changes in the Ca2+-exocytosis relationship during repetitive pulse protocols in bovine adrenal chromaffin cells. | lld:pubmed |
| pubmed-article:9364048 | pubmed:affiliation | Department of Neurobiology and Anatomy, Medical College of Pennsylvania-Hahnemann University, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19129, USA. | lld:pubmed |
| pubmed-article:9364048 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9364048 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9364048 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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