| pubmed-article:9361296 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9361296 | lifeskim:mentions | umls-concept:C0037657 | lld:lifeskim |
| pubmed-article:9361296 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:9361296 | lifeskim:mentions | umls-concept:C1518294 | lld:lifeskim |
| pubmed-article:9361296 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9361296 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:9361296 | pubmed:dateCreated | 1997-12-10 | lld:pubmed |
| pubmed-article:9361296 | pubmed:abstractText | Insulin-like growth factor I (IGF-I) and IGF-II are potent trophic factors for motor and sensory neurons and glial cells. The actions of IGF-I and IGF-II are mediated via the IGF-I receptor (IGF-IR). IGF:IGF-IR binding activates distinct signaling cascades, which in turn mediate the trophic effects of the IGFs. We discuss three main IGF coupled events: growth cone motility, long-term neurite outgrowth, and neuroprotection. Our data suggest that IGF-I enhances growth cone motility by promoting reorganization of actin and activation of focal adhesion proteins via the phosphatidylinositol-3 kinase (Pl-3K) pathway. Long-term treatment with IGF-I activates the mitogen-activated protein (MAP) kinase cascade and promotes neurite outgrowth. A separable, but likely linked, action of the IGFs via Pl-3K is protection of neurons from apoptosis. These pleotrophic effects of IGFs suggest that this family of growth factors may have potential clinical utility in the treatment of neurological disorders. | lld:pubmed |
| pubmed-article:9361296 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361296 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361296 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361296 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9361296 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361296 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9361296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361296 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9361296 | pubmed:issn | 0969-9961 | lld:pubmed |
| pubmed-article:9361296 | pubmed:author | pubmed-author:SullivanK AKA | lld:pubmed |
| pubmed-article:9361296 | pubmed:author | pubmed-author:KimBB | lld:pubmed |
| pubmed-article:9361296 | pubmed:author | pubmed-author:RussellJ WJW | lld:pubmed |
| pubmed-article:9361296 | pubmed:author | pubmed-author:FeldmanE LEL | lld:pubmed |
| pubmed-article:9361296 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9361296 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:9361296 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9361296 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9361296 | pubmed:pagination | 201-14 | lld:pubmed |
| pubmed-article:9361296 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9361296 | pubmed:meshHeading | pubmed-meshheading:9361296-... | lld:pubmed |
| pubmed-article:9361296 | pubmed:meshHeading | pubmed-meshheading:9361296-... | lld:pubmed |
| pubmed-article:9361296 | pubmed:meshHeading | pubmed-meshheading:9361296-... | lld:pubmed |
| pubmed-article:9361296 | pubmed:meshHeading | pubmed-meshheading:9361296-... | lld:pubmed |
| pubmed-article:9361296 | pubmed:meshHeading | pubmed-meshheading:9361296-... | lld:pubmed |
| pubmed-article:9361296 | pubmed:meshHeading | pubmed-meshheading:9361296-... | lld:pubmed |
| pubmed-article:9361296 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9361296 | pubmed:articleTitle | Insulin-like growth factors regulate neuronal differentiation and survival. | lld:pubmed |
| pubmed-article:9361296 | pubmed:affiliation | Department of Neurology, University of Michigan, Ann Arbor 48109, USA. | lld:pubmed |
| pubmed-article:9361296 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9361296 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9361296 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:9361296 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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