Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9351454rdf:typepubmed:Citationlld:pubmed
pubmed-article:9351454lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:9351454lifeskim:mentionsumls-concept:C0115305lld:lifeskim
pubmed-article:9351454lifeskim:mentionsumls-concept:C0225336lld:lifeskim
pubmed-article:9351454lifeskim:mentionsumls-concept:C1522318lld:lifeskim
pubmed-article:9351454lifeskim:mentionsumls-concept:C0003018lld:lifeskim
pubmed-article:9351454lifeskim:mentionsumls-concept:C1154393lld:lifeskim
pubmed-article:9351454lifeskim:mentionsumls-concept:C0127400lld:lifeskim
pubmed-article:9351454pubmed:issue5lld:pubmed
pubmed-article:9351454pubmed:dateCreated1997-12-2lld:pubmed
pubmed-article:9351454pubmed:abstractTextClinical data suggest a link between the activation of the renin-angiotensin system and cardiovascular ischemic events. Leukocyte accumulation in the vessel wall is a hallmark of early atherosclerosis and plaque progression. E-Selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) are adhesion molecules participating in mediating interactions between leukocytes and endothelial cells and have been found to be expressed in athero-sclerotic plaques. We investigated whether angiotensin II, the effector of the renin-angiotensin system, influences the endothelial expression of E-selectin, VCAM-1, and ICAM-1. In coronary endothelial cells derived from explanted human hearts, angiotensin II (10(-11) to 10(-5) mol/L) induced a concentration-dependent increase in E-selectin expression. The effect was measured by cell ELISA and duplex reverse-transcription polymerase chain reaction (RT-PCR) and reached its maximum at 10(-7) mol/L. Angiotensin II induced only a small increase in E-selectin expression in cardiac microvascular endothelial cells. VCAM-1 and ICAM-1 were not affected by angiotensin II stimulation. In addition, the effect of angiotensin II-induced E-selectin expression on leukocyte adhesion was quantified under flow conditions. Angiotensin II (10(-7) mol/L) increased leukocyte adhesion significantly to 67% of the maximal effect by tumor necrosis factor-alpha at a wall shear stress of 2 dyne/cm2. This adhesion was found to be E-selectin dependent, as demonstrated by blocking antibodies. The AT1-receptor antagonist DUP 753 significantly reduced E-selectin-dependent adhesion, whereas the AT2-receptor antagonist PD 123177 had no inhibitory effect. In addition, only AT1-receptor, but not AT2-receptor, mRNA could be detected by RT-PCR in coronary endothelial cells. Therefore, it is suggested that AT1 receptors mediate the effects of angiotensin II on E-selectin expression and leukocyte adhesion on coronary endothelial cells.lld:pubmed
pubmed-article:9351454pubmed:languageenglld:pubmed
pubmed-article:9351454pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9351454pubmed:citationSubsetIMlld:pubmed
pubmed-article:9351454pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9351454pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9351454pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9351454pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9351454pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9351454pubmed:statusMEDLINElld:pubmed
pubmed-article:9351454pubmed:monthNovlld:pubmed
pubmed-article:9351454pubmed:issn0009-7330lld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:GaehtgensPPlld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:GrafKKlld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:FleckEElld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:BartschPPlld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:GräfeMMlld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:Auch-SchwelkW...lld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:LoeblDDlld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:ZakrzewiczAAlld:pubmed
pubmed-article:9351454pubmed:authorpubmed-author:Regitz-Zagros...lld:pubmed
pubmed-article:9351454pubmed:issnTypePrintlld:pubmed
pubmed-article:9351454pubmed:volume81lld:pubmed
pubmed-article:9351454pubmed:ownerNLMlld:pubmed
pubmed-article:9351454pubmed:authorsCompleteYlld:pubmed
pubmed-article:9351454pubmed:pagination804-11lld:pubmed
pubmed-article:9351454pubmed:dateRevised2004-11-17lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:meshHeadingpubmed-meshheading:9351454-...lld:pubmed
pubmed-article:9351454pubmed:year1997lld:pubmed
pubmed-article:9351454pubmed:articleTitleAngiotensin II-induced leukocyte adhesion on human coronary endothelial cells is mediated by E-selectin.lld:pubmed
pubmed-article:9351454pubmed:affiliationDepartment of Internal Medicine/Cardiology, Virchow Klinikum, Humboldt University, Berlin, Germany.lld:pubmed
pubmed-article:9351454pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9351454lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9351454lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9351454lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9351454lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9351454lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9351454lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9351454lld:pubmed