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pubmed-article:9343103pubmed:abstractTextCharged-particle microbeams provide a unique opportunity to control precisely, the dose to individual cells and the localization of dose within the cell. The Gray Laboratory is now routinely operating a charged-particle microbeam capable of delivering targeted and counted particles to individual cells, at a dose-rate sufficient to permit a number of single-cell assays of radiation damage to be implemented. By this means, it is possible to study a number of important radiobiological processes in ways that cannot be achieved using conventional methods. This report describes the rationale, development and current capabilities of the Gray Laboratory microbeam.lld:pubmed
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pubmed-article:9343103pubmed:articleTitleA charged-particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles.lld:pubmed
pubmed-article:9343103pubmed:affiliationGray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK.lld:pubmed
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