| pubmed-article:9337482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9337482 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:9337482 | lifeskim:mentions | umls-concept:C0547040 | lld:lifeskim |
| pubmed-article:9337482 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9337482 | pubmed:dateCreated | 1997-11-24 | lld:pubmed |
| pubmed-article:9337482 | pubmed:abstractText | Recently, it was proposed that the thyroid hormone-mediated uncoupling in mitochondria is involved in the cellular defence system against free radicals (Skulachev V.P. (1996) Quart. Rev. Biophys. 29:169-202). This phenomenon was named "mild" uncoupling. It was postulated to be a protein-mediated process controlled by several factors. The data reported during the past 40 years, pointing to the protein-mediated uncoupling mechanism in mitochondria, are reviewed in a context of hypothetical properties of "mild" uncoupling. The mechanism of "mild" uncoupling is suggested to be the following: (a) mitochondria possess protein(s) that regulate the proton permeability of inner mitochondrial membrane; (b) these proteins are regulated by binding of an unidentified low-molecular-weight endogenous compound with properties resembling those of the most active artificial uncouplers like FCCP and SF6847; (c) the interaction of this compound with its target protein(s) is modulated by a thyroid hormone in a positive (i.e. enhancing the proton permeability) way and by sex steroid hormones in a negative way; (e) endogenous fatty acids can attenuate the influence of both thyroid and steroid hormones. | lld:pubmed |
| pubmed-article:9337482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9337482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9337482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9337482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9337482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9337482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9337482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9337482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9337482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9337482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9337482 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9337482 | pubmed:issn | 0144-8463 | lld:pubmed |
| pubmed-article:9337482 | pubmed:author | pubmed-author:StarkovA AAA | lld:pubmed |
| pubmed-article:9337482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9337482 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9337482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9337482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9337482 | pubmed:pagination | 273-9 | lld:pubmed |
| pubmed-article:9337482 | pubmed:dateRevised | 2005-11-16 | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:meshHeading | pubmed-meshheading:9337482-... | lld:pubmed |
| pubmed-article:9337482 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9337482 | pubmed:articleTitle | "Mild" uncoupling of mitochondria. | lld:pubmed |
| pubmed-article:9337482 | pubmed:affiliation | Department of Bioenergetics, A. N. Belozersky Institute for Physico-Chemical Biology, Moscow State University, Russia. | lld:pubmed |
| pubmed-article:9337482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9337482 | pubmed:publicationType | Review | lld:pubmed |
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