| pubmed-article:9335233 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9335233 | lifeskim:mentions | umls-concept:C0034823 | lld:lifeskim |
| pubmed-article:9335233 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9335233 | lifeskim:mentions | umls-concept:C0031586 | lld:lifeskim |
| pubmed-article:9335233 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9335233 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:9335233 | pubmed:dateCreated | 1997-10-31 | lld:pubmed |
| pubmed-article:9335233 | pubmed:abstractText | Granulosa cells have been used to study the regulation of LH/hCG receptor protein and mRNA expression. Phorbol 12-myristate 13-acetate (PMA) dose-dependently attenuates the increases in LH/hCG receptor mRNA and protein induced by FSH and forskolin (FSK). The presence of PMA caused a decrease in cAMP production stimulated by FSH and FSK. These results suggest that PMA-mediated decreases in cAMP are a major factor in PMA-mediated decreases in LH/hCG receptor mRNA. On the other hand, in the presence of 8-Br-cAMP, PMA significantly increased LH/hCG receptor mRNA and protein, with maximal stimulation between PMA concentrations of 3 to 30 nM (1.5 fold) with 8-Br-cAMP. These findings suggest that activation of protein kinase C by PMA attenuates the increase in cAMP accumulation induced by FSH but enhances the effect of cAMP on LH/hCG receptor expression, and that the inhibitory and stimulatory effects of PMA on LH/hCG receptor content are correlated with regulation of LH/hCG receptor mRNA levels. Since the half-life study revealed no change in the stability of the LH/hCG receptor mRNA following PMA treatment, a change in the rate of LH/hCG receptor gene transcription must be responsible for the change in the LH/hCG receptor mRNA levels. | lld:pubmed |
| pubmed-article:9335233 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9335233 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335233 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9335233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335233 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9335233 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:9335233 | pubmed:author | pubmed-author:MiyamotoKK | lld:pubmed |
| pubmed-article:9335233 | pubmed:author | pubmed-author:NakamuraKK | lld:pubmed |
| pubmed-article:9335233 | pubmed:author | pubmed-author:KamedaTT | lld:pubmed |
| pubmed-article:9335233 | pubmed:author | pubmed-author:KishiHH | lld:pubmed |
| pubmed-article:9335233 | pubmed:author | pubmed-author:TaneGG | lld:pubmed |
| pubmed-article:9335233 | pubmed:author | pubmed-author:MinegishiTT | lld:pubmed |
| pubmed-article:9335233 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9335233 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:9335233 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9335233 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9335233 | pubmed:pagination | 1435-43 | lld:pubmed |
| pubmed-article:9335233 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:meshHeading | pubmed-meshheading:9335233-... | lld:pubmed |
| pubmed-article:9335233 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9335233 | pubmed:articleTitle | Effect of phorbol ester on the regulation of LH/hCG receptors. | lld:pubmed |
| pubmed-article:9335233 | pubmed:affiliation | Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan. | lld:pubmed |
| pubmed-article:9335233 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9335233 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
