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pubmed-article:9328537pubmed:abstractTextMany studies on seasonality in Down syndrome (DS) have been performed and have come to different conclusions. It is suggested that seasonal variation in hormone production by the hypothalamus-pituitary-ovarian axis just before ovulation leads to seasonality in conception rates of DS. This study aimed to determine whether there is seasonal variation in the prevalence of DS at birth as a proxy for seasonality in DS at conception.lld:pubmed
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pubmed-article:9328537pubmed:authorpubmed-author:GabreëlsF JFJlld:pubmed
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pubmed-article:9328537pubmed:articleTitleSeasonal variation in the prevalence of Down syndrome at birth: a review.lld:pubmed
pubmed-article:9328537pubmed:affiliationDepartment of Medical Informatics, Epidemiology and Statistics, University of Nijmegen, The Netherlands.lld:pubmed
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