| pubmed-article:9321862 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9321862 | lifeskim:mentions | umls-concept:C0015967 | lld:lifeskim |
| pubmed-article:9321862 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9321862 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:9321862 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:9321862 | lifeskim:mentions | umls-concept:C1514555 | lld:lifeskim |
| pubmed-article:9321862 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:9321862 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
| pubmed-article:9321862 | pubmed:abstractText | The purpose of this study was to assess the effects of inhibitors of protein kinase C (PKC) on lipopolysaccharide (LPS)-induced fever and changes in circulating interleukin-6 (IL-6) levels in freely moving biotelemetered rats. We used PKC inhibitors with different inhibition constants (Ki): H-7 (Ki = 6 microM) and chelerythrine (Chel; Ki = 0.66 microM; a more potent PKC inhibitor). Rats were injected subcutaneously with either 3 or 15 microM/kg of these inhibitors and then 1 h later were injected intraperitoneally with LPS (50 micrograms/kg). Blood samples for IL-6 bioassay were collected 4 h after LPS injection. H-7 at lower doses did not significantly affect fever and LPS-induced elevation of circulating IL-6, whereas at a higher dose (15 microM/kg) H-7 reduced both fever and the increase of IL-6 (analysis of variance, Scheffé's test, P < 0.05). Chel (3 and 15 microM/kg) significantly reduced fever and almost completely inhibited the LPS-induced elevation of plasma IL-6. In separate experiments, we studied the effect of H-7 on antipyresis due to dexamethasone (Dex). Dex at a dose of 0.6 microM/kg given subcutaneously 1 h before LPS partially prevented fever (approximately 55% inhibition) and attenuated the increase of IL-6 (P < 0.05). Simultaneous pretreatment of the rats with Dex and H-7 (3 microM/kg; a dose that did not affect fever and IL-6 elevation) led to a potentiation of the antipyretic effect of Dex, resulting in no fever. H-7 did not potentiate, however, the inhibitory effect of Dex on LPS-induced elevation of circulating IL-6. We conclude that PKC is involved in the regulation of LPS fever and constitutes a rate-limiting factor in modulation of the fever by glucocorticoids. | lld:pubmed |
| pubmed-article:9321862 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9321862 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321862 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9321862 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9321862 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9321862 | pubmed:author | pubmed-author:ConnC ACA | lld:pubmed |
| pubmed-article:9321862 | pubmed:author | pubmed-author:KozakWW | lld:pubmed |
| pubmed-article:9321862 | pubmed:author | pubmed-author:KlugerM JMJ | lld:pubmed |
| pubmed-article:9321862 | pubmed:author | pubmed-author:KlirJ JJJ | lld:pubmed |
| pubmed-article:9321862 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9321862 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9321862 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9321862 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9321862 | pubmed:pagination | R873-9 | lld:pubmed |
| pubmed-article:9321862 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9321862 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9321862 | pubmed:articleTitle | Attenuation of lipopolysaccharide fever in rats by protein kinase C inhibitors. | lld:pubmed |
| pubmed-article:9321862 | pubmed:affiliation | Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA. | lld:pubmed |
| pubmed-article:9321862 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9321862 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9321862 | lld:pubmed |
