| pubmed-article:9316672 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9316672 | lifeskim:mentions | umls-concept:C0001688 | lld:lifeskim |
| pubmed-article:9316672 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:9316672 | lifeskim:mentions | umls-concept:C0879626 | lld:lifeskim |
| pubmed-article:9316672 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:9316672 | lifeskim:mentions | umls-concept:C0084396 | lld:lifeskim |
| pubmed-article:9316672 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9316672 | pubmed:dateCreated | 1997-10-31 | lld:pubmed |
| pubmed-article:9316672 | pubmed:abstractText | Catechol-O-methyl-transferase inhibitors are promising drugs in Parkinson's disease since these drugs enhance levodopa effects and increase their duration. However, since these compounds block a pathway for the peripheral metabolism of catecholamines, they may also produce side effects related to elevation of catecholamines in plasma. We investigated the adverse effects of Ro 40-7592 in rabbits and the relationship of Ro 40-7592 to norepinephrine plasma levels. Intravenous administration of Ro 40-7592 in rabbits induced elevation of norepinephrine plasma levels in old animals after bolus injection of a dose three times the highest dose actually recommended to be taken orally by humans. Though Ro 40-7592 appears safe for humans, special precautions may be needed in patients with a high risk of adrenergic hyperactivity. | lld:pubmed |
| pubmed-article:9316672 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9316672 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9316672 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9316672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9316672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9316672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9316672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9316672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9316672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9316672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9316672 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9316672 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9316672 | pubmed:issn | 0362-5664 | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:GüntherII | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:MenaM AMA | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:AntoniniAA | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:CorreaCC | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:de YébenesJ... | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:GarridoJ MJM | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:Jores | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:LeendersKK | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:PsyllaMM | lld:pubmed |
| pubmed-article:9316672 | pubmed:author | pubmed-author:HerrarasOO | lld:pubmed |
| pubmed-article:9316672 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9316672 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9316672 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9316672 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9316672 | pubmed:pagination | 270-6 | lld:pubmed |
| pubmed-article:9316672 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:meshHeading | pubmed-meshheading:9316672-... | lld:pubmed |
| pubmed-article:9316672 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:9316672 | pubmed:articleTitle | Side effects of the catechol-O-methyl-transferase inhibitor Ro 40-7592 in rabbits. | lld:pubmed |
| pubmed-article:9316672 | pubmed:affiliation | Departamento de Investigación, C. Ramón y Cajal, Madrid, Spain. | lld:pubmed |
| pubmed-article:9316672 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9316672 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9316672 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
