| pubmed-article:9312048 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9312048 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:9312048 | lifeskim:mentions | umls-concept:C0439742 | lld:lifeskim |
| pubmed-article:9312048 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:9312048 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:9312048 | lifeskim:mentions | umls-concept:C0443299 | lld:lifeskim |
| pubmed-article:9312048 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:9312048 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:9312048 | pubmed:dateCreated | 1997-12-10 | lld:pubmed |
| pubmed-article:9312048 | pubmed:abstractText | We have demonstrated previously that Src controls the epidermal growth factor (EGF)-induced dispersion of NBT-II carcinoma epithelial cells. Here we show that while only Src and Yes were expressed and activated by EGF, microinjected kinase-inactive mutants of Src (SrcK-) and Fyn (FynK-) were able to exert a dominant-negative effect on the scattering response. Both SH2 and SH3 domains of FynK- were required for inhibition of cell scattering. Expression of dominant-negative N17Ras also abrogated EGF-induced dispersion, showing that Ras is another regulator of cell dispersion. Expression of SrcK- did not alter EGF-evoked Shc tyrosine phosphorylation, Shc-Grb2 complex formation and MAPK activation, three elements of the Ras pathway. Furthermore, the expression of Jun-Fos and Slug rescued the block induced by N17Ras but not by SrcK-, showing that Src kinases and Ras operate in separate pathways. In addition, actinomycin D inhibition of RNA synthesis repressed the ability of the activated mutant L61Ras but not that of F527Src to induce epithelial cell scattering. Since tyrosine phosphorylation of cytoskeleton-associated proteins pp125FAK and cortactin were abolished in EGF-stimulated SrcK- cells, we concluded that, in contrast to Ras, Src kinases may control epithelial cell dispersion in the absence of gene expression and by directly regulating the organization of the cortical cytoskeleton. | lld:pubmed |
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| pubmed-article:9312048 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9312048 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9312048 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9312048 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9312048 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9312048 | pubmed:author | pubmed-author:ThieryJ PJP | lld:pubmed |
| pubmed-article:9312048 | pubmed:author | pubmed-author:BoyerBB | lld:pubmed |
| pubmed-article:9312048 | pubmed:author | pubmed-author:RocheSS | lld:pubmed |
| pubmed-article:9312048 | pubmed:author | pubmed-author:DenoyelleMM | lld:pubmed |
| pubmed-article:9312048 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9312048 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9312048 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:9312048 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9312048 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9312048 | pubmed:pagination | 5904-13 | lld:pubmed |
| pubmed-article:9312048 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:9312048 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9312048 | pubmed:articleTitle | Src and Ras are involved in separate pathways in epithelial cell scattering. | lld:pubmed |
| pubmed-article:9312048 | pubmed:affiliation | Laboratoire de Compartimentation et Dynamique cellulaires, UMR CNRS 144, Institut Curie Section de Recherche, 26 rue d'Ulm F-75248 Paris Cedex 05, France. bboyer@curie.fr | lld:pubmed |
| pubmed-article:9312048 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9312048 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9312048 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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