| pubmed-article:9311991 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0122111 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0812299 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0040132 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0007621 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0920532 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:9311991 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:9311991 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:9311991 | pubmed:dateCreated | 1997-12-15 | lld:pubmed |
| pubmed-article:9311991 | pubmed:abstractText | The expression of the high mobility group I (HMGI)-C chromatin component was shown previously to be essential for the establishment of the neoplastic phenotype in retrovirally transformed thyroid cell lines. To identify possible targets of the HMGI-C gene product, we have analyzed the AP-1 complex in normal, fully transformed and antisense HMGI-C-expressing rat thyroid cells. We show that neoplastic transformation is associated with a drastic increase in AP-1 activity, which reflects multiple compositional changes. The strongest effect is represented by the dramatic junB and fra-1 gene induction, which is prevented in cell lines expressing the antisense HMGI-C. These results indicate that the HMGI-C gene product is essential for the junB and fra-1 transcriptional induction associated with neoplastic transformation. The inhibition of Fra-1 protein synthesis by stable transfection with a fra-1 antisense RNA vector significantly reduces the malignant phenotype of the transformed thyroid cells, indicating a pivotal role for the fra-1 gene product in the process of cellular transformation. | lld:pubmed |
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| pubmed-article:9311991 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9311991 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9311991 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9311991 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9311991 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9311991 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:FuscoAA | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:SantoroMM | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:FedeleMM | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:VerdePP | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:BattistaSS | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:ValloneDD | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:VigliettoGG | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:CasalinoLL | lld:pubmed |
| pubmed-article:9311991 | pubmed:author | pubmed-author:PierantoniG... | lld:pubmed |
| pubmed-article:9311991 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9311991 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9311991 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:9311991 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9311991 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9311991 | pubmed:pagination | 5310-21 | lld:pubmed |
| pubmed-article:9311991 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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