| pubmed-article:9311895 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9311895 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9311895 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:9311895 | lifeskim:mentions | umls-concept:C0221912 | lld:lifeskim |
| pubmed-article:9311895 | lifeskim:mentions | umls-concept:C0439640 | lld:lifeskim |
| pubmed-article:9311895 | lifeskim:mentions | umls-concept:C0439962 | lld:lifeskim |
| pubmed-article:9311895 | lifeskim:mentions | umls-concept:C0242732 | lld:lifeskim |
| pubmed-article:9311895 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:9311895 | lifeskim:mentions | umls-concept:C1883725 | lld:lifeskim |
| pubmed-article:9311895 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9311895 | pubmed:dateCreated | 1997-10-20 | lld:pubmed |
| pubmed-article:9311895 | pubmed:abstractText | A report that genetic subtype E human immunodeficiency virus type 1 (HIV-1) strains display a preferential tropism for Langerhans cells (epidermal dendritic cells [DCs]) compared to genetic subtype B strains suggested a possible explanation for the rapid heterosexual spread of subtype E strains in Thailand (L. E. Soto-Ramirez et al., Science 271:1291-1293, 1996). In an independent system, we applied subtype E and B isolates to skin leukocytes, since skin is a relevant model for the histologically comparable surfaces of the vagina and ectocervix. Isolates of both HIV-1 subtypes infected DC-T-cell mixtures, and no subtype-specific pattern of infection was observed. Purified DCs did not support the replication of strains of either subtype B or E. Our findings do not support the conclusion that subtype E strains have a preferential tropism for DCs, suggesting that other explanations for the rapid heterosexual spread of subtype E strains in Asia should be considered. | lld:pubmed |
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| pubmed-article:9311895 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9311895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9311895 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9311895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9311895 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9311895 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9311895 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:BurkeD SDS | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:PopeMM | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:MooreJ PJP | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:CuqPP | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:TrkolaAA | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:BirxD LDL | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:MascolaJ RJR | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:FrankelS SSS | lld:pubmed |
| pubmed-article:9311895 | pubmed:author | pubmed-author:IsdellFF | lld:pubmed |
| pubmed-article:9311895 | pubmed:issnType | Print | lld:pubmed |
