| pubmed-article:9310832 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9310832 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9310832 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9310832 | pubmed:dateCreated | 1997-10-28 | lld:pubmed |
| pubmed-article:9310832 | pubmed:abstractText | Proliferative expansion and apoptotic cell death play prominent roles in T cell development. The molecular control of cell cycle progression and apoptosis appear to be inter-connected since the Bcl-2 protein can inhibit apoptosis and slow cell cycle progression in cortical thymocytes and mature T cells, particularly during the transition from the quiescent state into the cell cycle. Here the impact of bcl-2 transgene expression on CD3-CD4-CD8- T cell progenitors was assessed. Bcl-2 enhanced the survival of these progenitors at all of the four major differentiation stages, CD25- CD44+ (pro-T1), CD25 + CD44+ (pro-T2), CD25 + CD44- (pro-T3) and CD25-CD44- (pro-T4). However, it reduced cell cycling and slowed turnover only in the pro-T4 subset. From an analysis of bcl-2 transgenic mice expressing a TCR transgene or bearing a mutation in the scid or rag-1 gene we conclude that Bcl-2 inhibits proliferation only of T cell progenitors that are activated via the pre-TCR, not those stimulated via c-Kit and the IL-7 receptor. | lld:pubmed |
| pubmed-article:9310832 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9310832 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9310832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9310832 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9310832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9310832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9310832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9310832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9310832 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9310832 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9310832 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:9310832 | pubmed:author | pubmed-author:HarrisA WAW | lld:pubmed |
| pubmed-article:9310832 | pubmed:author | pubmed-author:O'ReillyL ALA | lld:pubmed |
| pubmed-article:9310832 | pubmed:author | pubmed-author:StrasserAA | lld:pubmed |
| pubmed-article:9310832 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9310832 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9310832 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9310832 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9310832 | pubmed:pagination | 1291-301 | lld:pubmed |
| pubmed-article:9310832 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9310832 | pubmed:meshHeading | pubmed-meshheading:9310832-... | lld:pubmed |
| pubmed-article:9310832 | pubmed:meshHeading | pubmed-meshheading:9310832-... | lld:pubmed |
| pubmed-article:9310832 | pubmed:meshHeading | pubmed-meshheading:9310832-... | lld:pubmed |
| pubmed-article:9310832 | pubmed:meshHeading | pubmed-meshheading:9310832-... | lld:pubmed |
| pubmed-article:9310832 | pubmed:meshHeading | pubmed-meshheading:9310832-... | lld:pubmed |
| pubmed-article:9310832 | pubmed:meshHeading | pubmed-meshheading:9310832-... | lld:pubmed |
| pubmed-article:9310832 | pubmed:meshHeading | pubmed-meshheading:9310832-... | lld:pubmed |
| pubmed-article:9310832 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9310832 | pubmed:articleTitle | bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors. | lld:pubmed |
| pubmed-article:9310832 | pubmed:affiliation | Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:9310832 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9310832 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9310832 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19090 | entrezgene:pubmed | pubmed-article:9310832 | lld:entrezgene |
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