| pubmed-article:9308918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0034069 | lld:lifeskim |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0205402 | lld:lifeskim |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0206063 | lld:lifeskim |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:9308918 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:9308918 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9308918 | pubmed:dateCreated | 1997-10-17 | lld:pubmed |
| pubmed-article:9308918 | pubmed:abstractText | Fibrosis of lung tissue is a frequent and serious consequence of radiotherapy of mammary carcinoma. The pathogenesis of radiation-induced pulmonary fibrosis remains unclear. Cytokines such as transforming growth factor beta (TGFbeta) and interleukin-4 (IL-4) have been reported to stimulate collagen synthesis in fibroblasts in vitro. The aim of this study was to document the presence of IL-4 during the development of post-irradiation lung fibrosis. Right lungs of male Fischer rats were irradiated with a single dose of 20 Gy and IL-4 expression in the irradiated lungs was monitored for a period of three months. IL-4 gene transcription as determined by ribonuclease protection assay (RPA) as well as IL-4 synthesis as shown by Western blotting increased in the irradiated lungs reaching a plateau concentration within 3 weeks after irradiation. Enhanced IL-4 production was still detected at day 84 after irradiation. The cellular origin of IL-4 was analyzed by in situ hybridization and two-color immunofluorescence on lung tissue sections and on cytospin preparations of leukocytes obtained from bronchoalveolar lavages. These experiments revealed a substantial IL-4 production by macrophages during development of post-irradiation lung fibrosis. | lld:pubmed |
| pubmed-article:9308918 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9308918 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9308918 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9308918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9308918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9308918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9308918 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9308918 | pubmed:issn | 1044-1549 | lld:pubmed |
| pubmed-article:9308918 | pubmed:author | pubmed-author:FrankK HKH | lld:pubmed |
| pubmed-article:9308918 | pubmed:author | pubmed-author:RieberE PEP | lld:pubmed |
| pubmed-article:9308918 | pubmed:author | pubmed-author:ReimannTT | lld:pubmed |
| pubmed-article:9308918 | pubmed:author | pubmed-author:BüttnerCC | lld:pubmed |
| pubmed-article:9308918 | pubmed:author | pubmed-author:GeyerPP | lld:pubmed |
| pubmed-article:9308918 | pubmed:author | pubmed-author:UntereggerGG | lld:pubmed |
| pubmed-article:9308918 | pubmed:author | pubmed-author:SkupinAA | lld:pubmed |
| pubmed-article:9308918 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9308918 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9308918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9308918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9308918 | pubmed:pagination | 315-25 | lld:pubmed |
| pubmed-article:9308918 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9308918 | pubmed:meshHeading | pubmed-meshheading:9308918-... | lld:pubmed |
| pubmed-article:9308918 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9308918 | pubmed:articleTitle | Local production of interleukin-4 during radiation-induced pneumonitis and pulmonary fibrosis in rats: macrophages as a prominent source of interleukin-4. | lld:pubmed |
| pubmed-article:9308918 | pubmed:affiliation | Institute of Immunology, Medical Faculty, Technical University Dresden, Germany. immunol@rcs.urz.tu-dresden.de | lld:pubmed |
| pubmed-article:9308918 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9308918 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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