| pubmed-article:9303190 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9303190 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:9303190 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:9303190 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9303190 | lifeskim:mentions | umls-concept:C0449445 | lld:lifeskim |
| pubmed-article:9303190 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9303190 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9303190 | pubmed:dateCreated | 1998-2-5 | lld:pubmed |
| pubmed-article:9303190 | pubmed:abstractText | A new method of stereoselective preparation of di(2'-deoxy or 2'-OMe)ribonucleoside (3',5')-methanephosphonate 5 is presented. The DBU/LiCl-assisted reaction of 5'-O-DMT-(2'-deoxy or 2'-OMe)ribonucleoside 3'-O-(S-alkyl methanephosphonothioate) 9 with 5'-OH nucleosides proceeds with full stereospecificity, giving 5 in moderate to good yield. The conversion of 5'-O-DMT-(2'-deoxy or 2'-OMe) ribonucleoside 3'-methanephosphonoanilidothioates 8 and 3'-O-methanephosphonoanilidates 10 by means of NaH/CX2 (X = O,S) followed by S-alkylation leads to monomers 9, with the possibility of use of both separated diastereomers of 8 for the preparation of one selected diastereomer of 5. The relative configuration at the P atom in 2'-OMe and deoxynucleoside derivatives of compounds 9 was established by means of stereoselective degradation of nucleoside 3'-O-methanephosphonothioates 11 (precursors of 9) with nuclease P1. | lld:pubmed |
| pubmed-article:9303190 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9303190 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9303190 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9303190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9303190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9303190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9303190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9303190 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9303190 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9303190 | pubmed:issn | 1087-2906 | lld:pubmed |
| pubmed-article:9303190 | pubmed:author | pubmed-author:StecW JWJ | lld:pubmed |
| pubmed-article:9303190 | pubmed:author | pubmed-author:NiewiarowskiW... | lld:pubmed |
| pubmed-article:9303190 | pubmed:author | pubmed-author:PyzowskiJJ | lld:pubmed |
| pubmed-article:9303190 | pubmed:author | pubmed-author:Wo?niakL ALA | lld:pubmed |
| pubmed-article:9303190 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9303190 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:9303190 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9303190 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9303190 | pubmed:pagination | 381-95 | lld:pubmed |
| pubmed-article:9303190 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9303190 | pubmed:meshHeading | pubmed-meshheading:9303190-... | lld:pubmed |
| pubmed-article:9303190 | pubmed:meshHeading | pubmed-meshheading:9303190-... | lld:pubmed |
| pubmed-article:9303190 | pubmed:meshHeading | pubmed-meshheading:9303190-... | lld:pubmed |
| pubmed-article:9303190 | pubmed:meshHeading | pubmed-meshheading:9303190-... | lld:pubmed |
| pubmed-article:9303190 | pubmed:meshHeading | pubmed-meshheading:9303190-... | lld:pubmed |
| pubmed-article:9303190 | pubmed:meshHeading | pubmed-meshheading:9303190-... | lld:pubmed |
| pubmed-article:9303190 | pubmed:meshHeading | pubmed-meshheading:9303190-... | lld:pubmed |
| pubmed-article:9303190 | pubmed:meshHeading | pubmed-meshheading:9303190-... | lld:pubmed |
| pubmed-article:9303190 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9303190 | pubmed:articleTitle | Novel cost-effective methanephosphonoanilidothioate approach to the stereoselective synthesis of dinucleoside (3',5')-methanephosphonates. | lld:pubmed |
| pubmed-article:9303190 | pubmed:affiliation | Department of Bioorganic Chemistry, Polish Academy of Sciences, Lód?, Poland. | lld:pubmed |
| pubmed-article:9303190 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9303190 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
