| pubmed-article:9299559 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9299559 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9299559 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
| pubmed-article:9299559 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:9299559 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:9299559 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:9299559 | lifeskim:mentions | umls-concept:C0303920 | lld:lifeskim |
| pubmed-article:9299559 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:9299559 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:9299559 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9299559 | pubmed:dateCreated | 1997-10-16 | lld:pubmed |
| pubmed-article:9299559 | pubmed:abstractText | Six inherited neurologic diseases, including Huntington's disease, result from the expansion of a CAG domain of the disease genes to produce a domain of more than 40 glutamines in the expressed protein. The mechanism by which expansion of this polyglutamine domain causes disease is unknown. Recent studies demonstrated oligomerization of polyglutamine-domain proteins in mammalian neurons. To study oligomerization of polyglutamine proteins and to identify heterologous protein interactions, varying length polyglutamine-green fluorescent protein fusion proteins were expressed in cultured COS-7 cells. The 19- and 35-glutamine fusion proteins (non-pathologic length) distributed diffusely throughout the cytoplasm. In contrast, 56- and 80-glutamine fusion proteins (pathologic length) formed fibrillar arrays resembling those previously observed in neurons in Huntington's disease and in a transgenic mouse model. These aggregates were intranuclear and intracytoplasmic. Intracytoplasmic aggregates were surrounded by collapsed intermediate filaments. The intermediate filament protein vimentin co-immunoisolated with expanded polyglutamine fusion proteins. This cellular model will expedite investigations into oligomerization of polyglutamine proteins and their interactions with other proteins. | lld:pubmed |
| pubmed-article:9299559 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9299559 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9299559 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9299559 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9299559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9299559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9299559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9299559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9299559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9299559 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9299559 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9299559 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:9299559 | pubmed:author | pubmed-author:MillerS ESE | lld:pubmed |
| pubmed-article:9299559 | pubmed:author | pubmed-author:RosesA DAD | lld:pubmed |
| pubmed-article:9299559 | pubmed:author | pubmed-author:StrittmatterW... | lld:pubmed |
| pubmed-article:9299559 | pubmed:author | pubmed-author:TsujiSS | lld:pubmed |
| pubmed-article:9299559 | pubmed:author | pubmed-author:BurkaJ FJF | lld:pubmed |
| pubmed-article:9299559 | pubmed:author | pubmed-author:HesterSS | lld:pubmed |
| pubmed-article:9299559 | pubmed:author | pubmed-author:OnoderaOO | lld:pubmed |
| pubmed-article:9299559 | pubmed:copyrightInfo | Copyright 1997 Academic Press. | lld:pubmed |
| pubmed-article:9299559 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9299559 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:9299559 | pubmed:volume | 238 | lld:pubmed |
| pubmed-article:9299559 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9299559 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9299559 | pubmed:pagination | 599-605 | lld:pubmed |
| pubmed-article:9299559 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9299559 | pubmed:meshHeading | pubmed-meshheading:9299559-... | lld:pubmed |
| pubmed-article:9299559 | pubmed:meshHeading | pubmed-meshheading:9299559-... | lld:pubmed |
| pubmed-article:9299559 | pubmed:meshHeading | pubmed-meshheading:9299559-... | lld:pubmed |
| pubmed-article:9299559 | pubmed:meshHeading | pubmed-meshheading:9299559-... | lld:pubmed |
| pubmed-article:9299559 | pubmed:meshHeading | pubmed-meshheading:9299559-... | lld:pubmed |
| pubmed-article:9299559 | pubmed:meshHeading | pubmed-meshheading:9299559-... | lld:pubmed |
| pubmed-article:9299559 | pubmed:meshHeading | pubmed-meshheading:9299559-... | lld:pubmed |
| pubmed-article:9299559 | pubmed:meshHeading | pubmed-meshheading:9299559-... | lld:pubmed |
| pubmed-article:9299559 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9299559 | pubmed:articleTitle | Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells. | lld:pubmed |
| pubmed-article:9299559 | pubmed:affiliation | Department of Medicine (Neurology), Duke University Medical Center, Durham, North Carolina 27710, USA. | lld:pubmed |
| pubmed-article:9299559 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9299559 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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