| pubmed-article:9296571 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C0004461 | lld:lifeskim |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C1180283 | lld:lifeskim |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C0289174 | lld:lifeskim |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:9296571 | lifeskim:mentions | umls-concept:C0445254 | lld:lifeskim |
| pubmed-article:9296571 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9296571 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
| pubmed-article:9296571 | pubmed:abstractText | Serotonin (5-hydroxytryptamine, 5-HT) is a well known inflammatory mediator and algesic substance. It has been hypothesized that 5-HT can have a direct action on peripheral sensory axons, but there has been no anatomical demonstration of 5-HT receptors on peripheral primary afferent processes. The present study shows that 32% of unmyelinated axons at the dermal-epidermal junction are immunohistochemically stained with antibodies directed against the 5-HT2A receptor providing anatomical evidence that 5-HT can have a direct effect on sensory fibers in the skin. Furthermore, encapsulated nerve endings in Pacinian corpuscles also contain reaction product following immunostaining for 5-HT2A receptors, indicating that large myelinated axons can be activated by endogenous serotonin. These data suggest that peripherally acting 5-HT2A antagonists may be effective in reducing pain of peripheral origin. | lld:pubmed |
| pubmed-article:9296571 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9296571 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9296571 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9296571 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9296571 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9296571 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9296571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9296571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9296571 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9296571 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9296571 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:9296571 | pubmed:author | pubmed-author:CoggeshallR... | lld:pubmed |
| pubmed-article:9296571 | pubmed:author | pubmed-author:CarltonS MSM | lld:pubmed |
| pubmed-article:9296571 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9296571 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:9296571 | pubmed:volume | 763 | lld:pubmed |
| pubmed-article:9296571 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9296571 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9296571 | pubmed:pagination | 271-5 | lld:pubmed |
| pubmed-article:9296571 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:meshHeading | pubmed-meshheading:9296571-... | lld:pubmed |
| pubmed-article:9296571 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9296571 | pubmed:articleTitle | Immunohistochemical localization of 5-HT2A receptors in peripheral sensory axons in rat glabrous skin. | lld:pubmed |
| pubmed-article:9296571 | pubmed:affiliation | Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555-1069, USA. | lld:pubmed |
| pubmed-article:9296571 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9296571 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9296571 | lld:pubmed |
