| pubmed-article:9278545 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9278545 | lifeskim:mentions | umls-concept:C1333669 | lld:lifeskim |
| pubmed-article:9278545 | lifeskim:mentions | umls-concept:C0597295 | lld:lifeskim |
| pubmed-article:9278545 | lifeskim:mentions | umls-concept:C0207072 | lld:lifeskim |
| pubmed-article:9278545 | lifeskim:mentions | umls-concept:C0040223 | lld:lifeskim |
| pubmed-article:9278545 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:9278545 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:9278545 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:9278545 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:9278545 | pubmed:dateCreated | 1997-10-3 | lld:pubmed |
| pubmed-article:9278545 | pubmed:abstractText | Glial cell line-derived neurotrophic factor (GDNF) injected intranigrally protects midbrain dopamine neurons against 6-hydroxydopamine (6-OHDA) toxicity. The timing between GDNF administration and exposure to 6-OHDA is critical in achieving optimal protection. When injected 6 hr before an intranigral injection of 6-OHDA, GDNF provides complete protection as measured by the number of surviving neurons in the substantia nigra of adult rats. The surviving neuronal population decreases by approximately 50% with 12 and 24 hr separating GDNF and 6-OHDA administrations. In controls with 6-OHDA lesions, there is <10% survival of nigral dopamine neurons. No significant increase in survival is seen with either concurrent injections of GDNF and 6-OHDA or 1 hr GDNF pretreatment. Based on HPLC measurements, striatal and midbrain dopamine levels are at least twofold higher on the lesioned side in animals receiving GDNF 6 hr before a 6-OHDA lesion compared with vehicle recipients. Protein synthesis is necessary for GDNF-induced neuroprotective effects because cycloheximide pretreatment that inhibits protein synthesis also blocks neuroprotection. | lld:pubmed |
| pubmed-article:9278545 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9278545 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9278545 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9278545 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9278545 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9278545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9278545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9278545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9278545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9278545 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9278545 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9278545 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:9278545 | pubmed:author | pubmed-author:GashD MDM | lld:pubmed |
| pubmed-article:9278545 | pubmed:author | pubmed-author:CassW AWA | lld:pubmed |
| pubmed-article:9278545 | pubmed:author | pubmed-author:KryscioRR | lld:pubmed |
| pubmed-article:9278545 | pubmed:author | pubmed-author:KearnsC MCM | lld:pubmed |
| pubmed-article:9278545 | pubmed:author | pubmed-author:SmootKK | lld:pubmed |
| pubmed-article:9278545 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9278545 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9278545 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9278545 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9278545 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9278545 | pubmed:pagination | 7111-8 | lld:pubmed |
| pubmed-article:9278545 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9278545 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9278545 | pubmed:articleTitle | GDNF protection against 6-OHDA: time dependence and requirement for protein synthesis. | lld:pubmed |
| pubmed-article:9278545 | pubmed:affiliation | Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA. | lld:pubmed |
| pubmed-article:9278545 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9278545 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9278545 | lld:pubmed |
