| pubmed-article:9277349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9277349 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9277349 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9277349 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:9277349 | lifeskim:mentions | umls-concept:C0034052 | lld:lifeskim |
| pubmed-article:9277349 | lifeskim:mentions | umls-concept:C0596019 | lld:lifeskim |
| pubmed-article:9277349 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9277349 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:9277349 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9277349 | pubmed:issue | 2 Pt 1 | lld:pubmed |
| pubmed-article:9277349 | pubmed:dateCreated | 1997-9-24 | lld:pubmed |
| pubmed-article:9277349 | pubmed:abstractText | We report the electrophysiological and functional properties of Ca(2+)-activated Cl- currents [ICl(Ca)] in rat pulmonary artery smooth muscle and the activation of these currents by the metabolic inhibitor cyanide. Caffeine and norepinephrine (NE) evoked both Ca(2+)-activated K+ currents [IK(Ca)] and ICl(Ca) currents in voltage-clamped myocytes (-50 mV). Niflumic acid (10 microM) reduced the caffeine-induced ICl(Ca) by approximately 64% and reversibly reduced NE-induced tension. Exposure of myocytes to cyanide (2-10 mM) induced a slowly developing inward current (-50 mV) in physiological and K(+)-free solutions, which was identified as ICl(Ca) on the basis of ion selectivity and Ca2+ dependence. Cyanide elevated cytosolic Ca2+ concentration, and this elevation was markedly inhibited by preexposure to caffeine and slightly inhibited by nisoldipine. During exposure to caffeine, the Ca(2+)-activated K+ current was also augmented. Cyanide markedly prolonged ICl(Ca) activated by caffeine, increasing the half-decay time from 3.5 (control) to 29 s (cyanide); the half-decay time of the caffeine-induced IK(Ca) was not significantly affected by cyanide. The results indicate that metabolic inhibition increases [Ca2+]i and activates a prolonged, depolarizing Cl- current in pulmonary artery myocytes. | lld:pubmed |
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| pubmed-article:9277349 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9277349 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9277349 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9277349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9277349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9277349 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9277349 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9277349 | pubmed:author | pubmed-author:YuMM | lld:pubmed |
| pubmed-article:9277349 | pubmed:author | pubmed-author:WangQQ | lld:pubmed |
| pubmed-article:9277349 | pubmed:author | pubmed-author:KotlikoffM... | lld:pubmed |
| pubmed-article:9277349 | pubmed:author | pubmed-author:WangY XYX | lld:pubmed |
| pubmed-article:9277349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9277349 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9277349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9277349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9277349 | pubmed:pagination | C520-30 | lld:pubmed |
| pubmed-article:9277349 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9277349 | pubmed:meshHeading | pubmed-meshheading:9277349-... | lld:pubmed |
| pubmed-article:9277349 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9277349 | pubmed:articleTitle | Ca(2+)-activated Cl- currents are activated by metabolic inhibition in rat pulmonary artery smooth muscle cells. | lld:pubmed |
| pubmed-article:9277349 | pubmed:affiliation | Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6046, USA. | lld:pubmed |
| pubmed-article:9277349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9277349 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9277349 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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