| pubmed-article:9276744 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9276744 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9276744 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:9276744 | lifeskim:mentions | umls-concept:C0030805 | lld:lifeskim |
| pubmed-article:9276744 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:9276744 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:9276744 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9276744 | pubmed:dateCreated | 1997-9-25 | lld:pubmed |
| pubmed-article:9276744 | pubmed:abstractText | Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with an IgG autoimmune response to the hemidesmosomal protein, BP180. Using a passive transfer mouse model, our group has shown previously that antibodies to the murine BP180 (mBP180) ectodomain are capable of triggering a blistering skin disease that closely mimics human BP. In this study, we investigated the role of neutrophils in the immunopathogenesis of this disease model. BALB/c mice depleted of circulating neutrophils by treatment with neutrophil-specific antibodies were no longer susceptible to the pathogenic effects of anti-mBP180 IgG. IgG and complement were deposited at the dermal-epidermal junction of these animals, but there was no evidence of inflammatory infiltration or blistering. C5-deficient mice, which are resistant to the pathogenic activity of anti-mBP180 IgG, could be made susceptible to this IgG-mediated blistering disease by intradermal administration of a neutrophil chemoattractant, IL-8 or C5a. Intraperitoneal injection of IL-8, which sequesters neutrophils in the peritoneal cavity, interferes with anti-mBP180-induced neutrophilic infiltration of the skin and prevented the development of BP disease in BALB/c mice. These findings provide the first direct evidence that neutrophils recruited to the skin via a C5-dependent pathway play an essential role in subepidermal blister formation in experimental BP, and suggest new directions for disease intervention. | lld:pubmed |
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| pubmed-article:9276744 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9276744 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9276744 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9276744 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9276744 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9276744 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9276744 | pubmed:author | pubmed-author:LimRR | lld:pubmed |
| pubmed-article:9276744 | pubmed:author | pubmed-author:TroyJ LJL | lld:pubmed |
| pubmed-article:9276744 | pubmed:author | pubmed-author:DiazL ALA | lld:pubmed |
| pubmed-article:9276744 | pubmed:author | pubmed-author:ZhouXX | lld:pubmed |
| pubmed-article:9276744 | pubmed:author | pubmed-author:TillG OGO | lld:pubmed |
| pubmed-article:9276744 | pubmed:author | pubmed-author:GiudiceG JGJ | lld:pubmed |
| pubmed-article:9276744 | pubmed:author | pubmed-author:FairleyJ AJA | lld:pubmed |
| pubmed-article:9276744 | pubmed:author | pubmed-author:SwartzS JSJ | lld:pubmed |
| pubmed-article:9276744 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9276744 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9276744 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:9276744 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9276744 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9276744 | pubmed:pagination | 1256-63 | lld:pubmed |
| pubmed-article:9276744 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:9276744 | pubmed:meshHeading | pubmed-meshheading:9276744-... | lld:pubmed |
| pubmed-article:9276744 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9276744 | pubmed:articleTitle | A major role for neutrophils in experimental bullous pemphigoid. | lld:pubmed |
| pubmed-article:9276744 | pubmed:affiliation | Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. zhiliu@post.its.mcw.edu | lld:pubmed |
| pubmed-article:9276744 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9276744 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9276744 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9276744 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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