| pubmed-article:9276742 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0344335 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0008662 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C1521048 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0597336 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0023745 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:9276742 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:9276742 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9276742 | pubmed:dateCreated | 1997-9-25 | lld:pubmed |
| pubmed-article:9276742 | pubmed:abstractText | Chromosomal synteny between the mouse model and humans was used to map a gene for the complex trait of obesity. Analysis of NZB/BINJ x SM/J intercross mice located a quantitative trait locus (QTL) for obesity on distal mouse chromosome 2, in a region syntenic with a large region of human chromosome 20, showing linkage to percent body fat (likelihood of the odds [LOD] score 3.6) and fat mass (LOD score 4.3). The QTL was confirmed in a congenic mouse strain. To test whether the QTL contributes to human obesity, we studied linkage between markers located within a 52-cM region extending from 20p12 to 20q13.3 and measures of obesity in 650 French Canadian subjects from 152 pedigrees participating in the Quebec Family Study. Sib-pair analysis based on a maximum of 258 sib pairs revealed suggestive linkages between the percentage of body fat (P < 0.004), body mass index (P < 0.008), and fasting insulin (P < 0.0005) and a locus extending approximately from ADA (the adenosine deaminase gene) to MC3R (the melanocortin 3 receptor gene). These data provide evidence that a locus on human chromosome 20q contributes to body fat and insulin in a human population, and demonstrate the utility of using interspecies syntenic relationships to find relevant disease loci in humans. | lld:pubmed |
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| pubmed-article:9276742 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9276742 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9276742 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9276742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9276742 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9276742 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9276742 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:LusisA JAJ | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:DionneF TFT | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:BouchardCC | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:NadeauAA | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:GagnonJJ | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:FislerJ SJS | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:WardenC HCH | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:PérusseLL | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:Purcell-Huynh... | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:LembertasA... | lld:pubmed |
| pubmed-article:9276742 | pubmed:author | pubmed-author:ChagnonY CYC | lld:pubmed |
| pubmed-article:9276742 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9276742 | pubmed:day | 1 | lld:pubmed |
