| pubmed-article:9268497 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9268497 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:9268497 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:9268497 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9268497 | lifeskim:mentions | umls-concept:C1511646 | lld:lifeskim |
| pubmed-article:9268497 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:9268497 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9268497 | lifeskim:mentions | umls-concept:C0059386 | lld:lifeskim |
| pubmed-article:9268497 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9268497 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9268497 | pubmed:dateCreated | 1997-9-19 | lld:pubmed |
| pubmed-article:9268497 | pubmed:abstractText | It has been proposed that superantigens are involved in the pathogenesis of autoimmune diseases. To test the possibility of superantigens inducing arthritis in naive mice, V beta 8-reactive superantigen staphylococcal enterotoxin B (SEB) was injected into naive mice. We used female DBA/1 mice, because they were susceptible to collagen-induced arthritis (CIA), in which the pathogenic T cells were supposed to preferentially use limited V betas of T cell receptors including V beta 8. Mild monoarthritis developed in uninjected hindlimbs of mice administered with SEB in higher frequency (an average incidence of 24%) than the control phosphate-buffered saline-injected mice (4.2%). Autoimmune responses in mice administered with SEB were compared with those in mice developing CIA. However, activation of type II collagen (IIC)-reactive T cells was not detected in SEB-injected mice. Production of autoantibodies, anti-IIC antibody and rheumatoid factor was also undetected. Although exact mechanisms of pathogenesis of this arthritis remain to be known, V beta 8+ T cells were activated for a long period and the unresponsiveness of V beta 8+ T cells was not detected in this strain. From these results, we discuss the pathogenesis of arthritis induced by SEB and the possibility that superantigen may play a role in the induction of autoimmune diseases. | lld:pubmed |
| pubmed-article:9268497 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9268497 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268497 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9268497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268497 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9268497 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9268497 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:9268497 | pubmed:author | pubmed-author:SasakiTT | lld:pubmed |
| pubmed-article:9268497 | pubmed:author | pubmed-author:YamashitaUU | lld:pubmed |
| pubmed-article:9268497 | pubmed:author | pubmed-author:KakimotoKK | lld:pubmed |
| pubmed-article:9268497 | pubmed:author | pubmed-author:OmataSS | lld:pubmed |
| pubmed-article:9268497 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9268497 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9268497 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:9268497 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9268497 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9268497 | pubmed:pagination | 138-45 | lld:pubmed |
| pubmed-article:9268497 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:meshHeading | pubmed-meshheading:9268497-... | lld:pubmed |
| pubmed-article:9268497 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9268497 | pubmed:articleTitle | Staphylococcal enterotoxin B induces arthritis in female DBA/1 mice but fails to induce activation of type II collagen-reactive lymphocytes. | lld:pubmed |
| pubmed-article:9268497 | pubmed:affiliation | Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyusyu, Japan. | lld:pubmed |
| pubmed-article:9268497 | pubmed:publicationType | Journal Article | lld:pubmed |
