| pubmed-article:9268336 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C0031603 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C0074512 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C0041532 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C2612389 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:9268336 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:9268336 | pubmed:issue | 35 | lld:pubmed |
| pubmed-article:9268336 | pubmed:dateCreated | 1997-10-2 | lld:pubmed |
| pubmed-article:9268336 | pubmed:abstractText | Approximately 90% of human U6 small nuclear RNA (snRNA) contains uridine cyclic phosphate (U>p) at its 3'-end (Lund, E., and Dahlberg, J. E. (1992) Science 255, 327-330). We studied the formation of U>p at the 3' end of human U6 snRNA using an in vitro system where uridylic acid residues are added from UTP precursor and U>p is formed. Analysis of U6 snRNAs with varying number of uridylic acid residues showed that each of these species contains U>p where the phosphate originated from alpha-phosphate of UTP precursor. The cyclic phosphate formation occurred on U6 snRNA in extracts where essential spliceosomal snRNAs were specifically degraded, thereby indicating that U>p formation is not coupled to pre-mRNA splicing. A subpopulation of human signal recognition particle and mitochondrial RNA processing RNAs isolated from HeLa cells also contained cyclic phosphates at their 3' ends. These data suggest that U>p in U6 snRNA is unlikely to be related to its participation in splicing of pre-mRNAs. It appears that cyclic phosphate is an intermediate product in the metabolism of these small RNAs. | lld:pubmed |
| pubmed-article:9268336 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268336 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9268336 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268336 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9268336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9268336 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9268336 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9268336 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9268336 | pubmed:author | pubmed-author:ReddyRR | lld:pubmed |
| pubmed-article:9268336 | pubmed:author | pubmed-author:HUII | lld:pubmed |
| pubmed-article:9268336 | pubmed:author | pubmed-author:MakanNN | lld:pubmed |
| pubmed-article:9268336 | pubmed:author | pubmed-author:ShumyatskyGG | lld:pubmed |
| pubmed-article:9268336 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9268336 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:9268336 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:9268336 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9268336 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9268336 | pubmed:pagination | 21989-93 | lld:pubmed |
| pubmed-article:9268336 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:meshHeading | pubmed-meshheading:9268336-... | lld:pubmed |
| pubmed-article:9268336 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9268336 | pubmed:articleTitle | Formation of 2',3'-cyclic phosphates at the 3' end of human U6 small nuclear RNA in vitro. Identification of 2',3'-cyclic phosphates at the 3' ends of human signal recognition particle and mitochondrial RNA processing RNAs. | lld:pubmed |
| pubmed-article:9268336 | pubmed:affiliation | Baylor College of Medicine, Department of Pharmacology, Houston, Texas 77030, USA. | lld:pubmed |
| pubmed-article:9268336 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9268336 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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