Linked Life Data

9263478

Source:http://linkedlifedata.com/resource/pubmed/id/9263478

Statements in which the resource exists.
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pubmed-article:9263478pubmed:abstractTextSpontaneous mouse mutations that cause severe immunodeficiency or autoimmunity are invaluable tools with which to investigate the mammalian immune system. Mutations at the 'motheaten' locus result in severe immunological dysfunction due to disruption of the structural gene encoding Src-homology 2-domain phosphatase-1 (SHP-1). This natural model for a specific protein-tyrosine-phosphatase deficiency is being widely utilized to determine the role of SHP-1 in the negative regulation of multiple signaling pathways in a number of hematopoietic lineages.lld:pubmed
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pubmed-article:9263478pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:9263478pubmed:articleTitleSevere defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.lld:pubmed
pubmed-article:9263478pubmed:affiliationJackson Laboratory, Bar Harbor, ME 04609, USA. lds@aretha.jax.orglld:pubmed
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