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pubmed-article:9255887pubmed:abstractTextThe antimicrobial resistance patterns and plasmid profiles of Salmonella typhi isolates from sporadic cases (n = 33) and an outbreak (n = 48) were compared. Of 28 sporadic drug-resistant isolates, 24 (85.7%) were multiply resistant. The predominant antibiotic resistance pattern was TeCmSmSxTAp, which was also the most common pattern of the outbreak isolates. 13 drug-resistant strains isolated before the outbreak (46.4%) were able to transfer the whole resistance pattern or part of it to Escherichia coli K 12 by conjugation. Although 20 of the sporadic strains contained plasmid DNA, transferable R plasmids were only detected in 13 (65%) of them. Among the outbreak strains, the rate of R plasmid transfer was 92.3%, with only the TeCmSmSxTAp pattern transferred. Plasmid profiling and Hind III endonuclease digestion of plasmid DNA identified a 91.2 megadaltons (Mda) plasmid that was recovered from most of the outbreak isolates and from 4 strains collected before the outbreak. This plasmid coded for TeCmSmSxtAp and transferred the pattern of resistance in toto. The results indicate multidrug-resistant S. typhi as a potential cause of infection in the region.lld:pubmed
pubmed-article:9255887pubmed:languageenglld:pubmed
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pubmed-article:9255887pubmed:authorpubmed-author:BahrmandA RARlld:pubmed
pubmed-article:9255887pubmed:authorpubmed-author:VelayatiA AAAlld:pubmed
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pubmed-article:9255887pubmed:volume29lld:pubmed
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pubmed-article:9255887pubmed:pagination265-9lld:pubmed
pubmed-article:9255887pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9255887pubmed:year1997lld:pubmed
pubmed-article:9255887pubmed:articleTitleAntimicrobial resistance pattern and plasmid profile of Salmonella typhi isolated from an outbreak in Tehran province.lld:pubmed
pubmed-article:9255887pubmed:affiliationMolecular Microbiology Unit, Pasteur Institute of Iran, Tehran, Islamic Republic of Iran.lld:pubmed
pubmed-article:9255887pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9255887pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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