Linked Life Data

9254677

Source:http://linkedlifedata.com/resource/pubmed/id/9254677

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9254677rdf:typepubmed:Citationlld:pubmed
pubmed-article:9254677lifeskim:mentionsumls-concept:C0288881lld:lifeskim
pubmed-article:9254677lifeskim:mentionsumls-concept:C1704675lld:lifeskim
pubmed-article:9254677lifeskim:mentionsumls-concept:C0439857lld:lifeskim
pubmed-article:9254677lifeskim:mentionsumls-concept:C0598964lld:lifeskim
pubmed-article:9254677lifeskim:mentionsumls-concept:C0596235lld:lifeskim
pubmed-article:9254677lifeskim:mentionsumls-concept:C0439799lld:lifeskim
pubmed-article:9254677lifeskim:mentionsumls-concept:C1515926lld:lifeskim
pubmed-article:9254677lifeskim:mentionsumls-concept:C0332453lld:lifeskim
pubmed-article:9254677pubmed:issue17lld:pubmed
pubmed-article:9254677pubmed:dateCreated1997-9-23lld:pubmed
pubmed-article:9254677pubmed:abstractTextPresynaptic N-type calcium channels interact with syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) through a binding site in the intracellular loop connecting domains II and III of the alpha1 subunit. This binding region was loaded into embryonic spinal neurons of Xenopus by early blastomere injection. After culturing, synaptic transmission of peptide-loaded and control cells was compared by measuring postsynaptic responses under different external Ca2+ concentrations. The relative transmitter release of injected neurons was reduced by approximately 25% at physiological Ca2+ concentration, whereas injection of the corresponding region of the L-type Ca2+ channel had virtually no effect. When applied to a theoretical model, these results imply that 70% of the formerly linked vesicles have been uncoupled after action of the peptide. Our data suggest that severing the physical interaction between presynaptic calcium channels and synaptic proteins will not prevent synaptic transmission at this synapse but will make it less efficient by shifting its Ca2+ dependence to higher values.lld:pubmed
pubmed-article:9254677pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:languageenglld:pubmed
pubmed-article:9254677pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:citationSubsetIMlld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9254677pubmed:statusMEDLINElld:pubmed
pubmed-article:9254677pubmed:monthSeplld:pubmed
pubmed-article:9254677pubmed:issn0270-6474lld:pubmed
pubmed-article:9254677pubmed:authorpubmed-author:CatterallW...lld:pubmed
pubmed-article:9254677pubmed:authorpubmed-author:NeherEElld:pubmed
pubmed-article:9254677pubmed:authorpubmed-author:YokoyamaC TCTlld:pubmed
pubmed-article:9254677pubmed:authorpubmed-author:RettieTTlld:pubmed
pubmed-article:9254677pubmed:authorpubmed-author:HeinemannCClld:pubmed
pubmed-article:9254677pubmed:authorpubmed-author:ShengZ HZHlld:pubmed
pubmed-article:9254677pubmed:authorpubmed-author:AsheryUUlld:pubmed
pubmed-article:9254677pubmed:issnTypePrintlld:pubmed
pubmed-article:9254677pubmed:day1lld:pubmed
pubmed-article:9254677pubmed:volume17lld:pubmed
pubmed-article:9254677pubmed:ownerNLMlld:pubmed
pubmed-article:9254677pubmed:authorsCompleteYlld:pubmed
pubmed-article:9254677pubmed:pagination6647-56lld:pubmed
pubmed-article:9254677pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:meshHeadingpubmed-meshheading:9254677-...lld:pubmed
pubmed-article:9254677pubmed:year1997lld:pubmed
pubmed-article:9254677pubmed:articleTitleAlteration of Ca2+ dependence of neurotransmitter release by disruption of Ca2+ channel/syntaxin interaction.lld:pubmed
pubmed-article:9254677pubmed:affiliationDepartment of Membrane Biophysics, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany.lld:pubmed
pubmed-article:9254677pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9254677pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9254677pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9254677lld:pubmed