| pubmed-article:9252029 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0042153 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0034705 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0373440 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0007818 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0428714 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:9252029 | lifeskim:mentions | umls-concept:C0058978 | lld:lifeskim |
| pubmed-article:9252029 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9252029 | pubmed:dateCreated | 1997-9-24 | lld:pubmed |
| pubmed-article:9252029 | pubmed:abstractText | The objective of this study was to determine the effect of ethyl eicosopentate (EPA-E) on local cerebral blood flow (1-CBF) and local glucose utilization (1-CGU) in specific regions of the brain in stroke-prone spontaneously hypertensive rats (SHRSP). EPA-E (100 mg/kg body weight) or saline was orally administered to 8-week-old SHRSP. L-CBF and 1-CGU in the EPA-E-treated, saline-treated, and 8-week-old control rats were measured autoradiographically using 14C-iodoantipyrine and 14C-deoxyglucose (Sakurada's and Sokoloff's methods). The 1-CBF of the saline-treated group decreased significantly with age in all areas measured. EPA-E treatment alleviated the age-dependent decrease in 1-CBF in all areas, especially those in the basal ganglia. The 1-CGU of the saline-treated group did not change with age, however EPA-E treatment increased 1-CGU in all areas measured, though the changes were not significant. EPA-E ameliorated the decrease in cerebral blood flow and improved glucose metabolism in SHRSP suffering from severe hypertension. These results suggest that EPA-E may be useful in the prevention of stroke. | lld:pubmed |
| pubmed-article:9252029 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9252029 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252029 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9252029 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252029 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252029 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252029 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252029 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9252029 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9252029 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:9252029 | pubmed:author | pubmed-author:KatayamaYY | lld:pubmed |
| pubmed-article:9252029 | pubmed:author | pubmed-author:KatsumataTT | lld:pubmed |
| pubmed-article:9252029 | pubmed:author | pubmed-author:MuramatsuHH | lld:pubmed |
| pubmed-article:9252029 | pubmed:author | pubmed-author:UsudaKK | lld:pubmed |
| pubmed-article:9252029 | pubmed:author | pubmed-author:TerashiAA | lld:pubmed |
| pubmed-article:9252029 | pubmed:author | pubmed-author:OboRR | lld:pubmed |
| pubmed-article:9252029 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9252029 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:9252029 | pubmed:volume | 761 | lld:pubmed |
| pubmed-article:9252029 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9252029 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9252029 | pubmed:pagination | 300-5 | lld:pubmed |
| pubmed-article:9252029 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:meshHeading | pubmed-meshheading:9252029-... | lld:pubmed |
| pubmed-article:9252029 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9252029 | pubmed:articleTitle | Effect of long-term administration of ethyl eicosapentate (EPA-E) on local cerebral blood flow and glucose utilization in stroke-prone spontaneously hypertensive rats (SHRSP). | lld:pubmed |
| pubmed-article:9252029 | pubmed:affiliation | Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan. | lld:pubmed |
| pubmed-article:9252029 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9252029 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9252029 | lld:pubmed |
