| pubmed-article:9250810 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9250810 | lifeskim:mentions | umls-concept:C1257751 | lld:lifeskim |
| pubmed-article:9250810 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9250810 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9250810 | lifeskim:mentions | umls-concept:C0665518 | lld:lifeskim |
| pubmed-article:9250810 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9250810 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:9250810 | pubmed:dateCreated | 1997-9-24 | lld:pubmed |
| pubmed-article:9250810 | pubmed:abstractText | Expression of T, sialosyl-T and disialosyl-T antigens on normal blood and bone marrow cells as well as transformed cells was examined using specific monoclonal antibodies and multidimensional flow cytometry. Both anti-sialosyl-T (QSH1) and anti-disialosyl-T (QSH2) monoclonal antibodies aggregated erythrocytes. The anti-disialosyl-T antibody was specific for the erythroid lineage and did not react with neutrophils, monocytes or T-lymphocytes, while the anti-sialosyl-T antibody reacted with erythroid cells and a subset of T-lymphocytes. The developing erythroid cells in bone marrow showed coordinate expression of glycophorin A and the two carbohydrate chains, sialosyl-T and disialosyl-T. Analysis of neoplastic cells showed that the anti-disialosyl-T antibody only reacted with glycophorin A-positive blasts from erythroleukemia (FAB M6) patients (4/4) and one patient with chronic myeloid leukemia in erythroblastic transformation (CMLET). Leukemic blasts from these patients demonstrated coordinate quantitative expression of glycophorin A and disialosyl-T. The anti-sialosyl-T antibody reacted with glycophorin A-positive blasts from FAB M6 patients (4/4) and one CMLET patient; however, the antibody also reacted with glycophorin A-negative blasts from one FAB M6 and the one CMLET patients and transformed cells from other types of leukemia. The anti-T monoclonal antibody (HH8) did not react with any of the other cells tested. These results indicate that glycophorin A and disialosyl-T expression are tightly linked during normal erythroid development and erythroid leukemogenesis. | lld:pubmed |
| pubmed-article:9250810 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9250810 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9250810 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9250810 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9250810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9250810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9250810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9250810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9250810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9250810 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9250810 | pubmed:month | May | lld:pubmed |
| pubmed-article:9250810 | pubmed:issn | 1042-8194 | lld:pubmed |
| pubmed-article:9250810 | pubmed:author | pubmed-author:MiuraYY | lld:pubmed |
| pubmed-article:9250810 | pubmed:author | pubmed-author:MONEYNN | lld:pubmed |
| pubmed-article:9250810 | pubmed:author | pubmed-author:AmemiyaYY | lld:pubmed |
| pubmed-article:9250810 | pubmed:author | pubmed-author:MuroiKK | lld:pubmed |
| pubmed-article:9250810 | pubmed:author | pubmed-author:SieversE LEL | lld:pubmed |
| pubmed-article:9250810 | pubmed:author | pubmed-author:HakamoriS ISI | lld:pubmed |
| pubmed-article:9250810 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9250810 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:9250810 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9250810 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9250810 | pubmed:pagination | 403-14 | lld:pubmed |
| pubmed-article:9250810 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:meshHeading | pubmed-meshheading:9250810-... | lld:pubmed |
| pubmed-article:9250810 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9250810 | pubmed:articleTitle | Expression of sialosyl-T and disialosyl-T antigens in erythroid cells. | lld:pubmed |
| pubmed-article:9250810 | pubmed:affiliation | Division of Transfusion Medicine, Jichi Medical School, Minamikawachi-machi, Tochigi-ken, Japan. | lld:pubmed |
| pubmed-article:9250810 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9250810 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9250810 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:9250810 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
