| pubmed-article:9249576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9249576 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9249576 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:9249576 | lifeskim:mentions | umls-concept:C0162640 | lld:lifeskim |
| pubmed-article:9249576 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:9249576 | lifeskim:mentions | umls-concept:C0026667 | lld:lifeskim |
| pubmed-article:9249576 | lifeskim:mentions | umls-concept:C0034798 | lld:lifeskim |
| pubmed-article:9249576 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:9249576 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9249576 | pubmed:issue | 1 Pt 2 | lld:pubmed |
| pubmed-article:9249576 | pubmed:dateCreated | 1997-9-3 | lld:pubmed |
| pubmed-article:9249576 | pubmed:abstractText | A 7-day exposure of tilapia (Oreochromis mossambicus) to water with a pH of 4.5 activates their pituitary melanophore-stimulating hormone (MSH) cells to preferentially release diacetyl alpha-MSH as an important corticotrope (13). We here focus on the control of alpha-MSH release by dopamine in tilapia exposed to water with low pH ("low-pH tilapia"). The MSH cells of low-pH tilapia showed a decreased sensitivity to inhibitory concentrations (10(-7)-10(-5) M) of dopamine compared with controls. Low concentrations (10(-14)-10(-8) M) of dopamine stimulated the release of alpha-MSH in low-pH tilapia but not in controls. Strong pharmacological evidence for a stimulatory dopamine receptor (D1-like) was obtained: the D1-agonists SKF-38393 and 6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazep ine hydrobromide (6-chloro APB) had a stimulatory effect on the release of alpha-MSH in low-pH tilapia MSH cells but not in controls. The selective D2-agonists quinpirole and 2-hydroxy apomorphin inhibited the release of alpha-MSH in controls as well as in low-pH tilapia, and there was no difference in the sensitivity of the cells to these agonists. We conclude that only MSH cells of low-pH exposed tilapia exhibit a D1-like receptor activity. A comparable D2-like receptor activity, as demonstrated by specific D2-receptor agonists, is present in both controls and low-pH-adapted fish. The apparent loss of sensitivity of the MSH cells to inhibitory concentrations of dopamine, therefore, must be caused by the activation of the D1-like receptors and not by changes in the activity of the D2-like receptor proper. Stimulatory concentrations of dopamine not only quantitatively but also qualitatively enhanced the corticotropic activity of the released alpha-MSH, as indicated by the elevated ratio of diacetyl and monoacetyl alpha-MSH. This effect was mimicked by the D1-like agonists SKF-38393 and 6-chloro APB, indicating that the D1-like receptor activity is responsible for the enhancement of the di/mono ratio. | lld:pubmed |
| pubmed-article:9249576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9249576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9249576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9249576 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9249576 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9249576 | pubmed:author | pubmed-author:Wendelaar... | lld:pubmed |
| pubmed-article:9249576 | pubmed:author | pubmed-author:FlikGG | lld:pubmed |
| pubmed-article:9249576 | pubmed:author | pubmed-author:LamersA EAE | lld:pubmed |
| pubmed-article:9249576 | pubmed:author | pubmed-author:Ter BruggeP... | lld:pubmed |
| pubmed-article:9249576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9249576 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9249576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9249576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9249576 | pubmed:pagination | R387-92 | lld:pubmed |
| pubmed-article:9249576 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9249576 | pubmed:meshHeading | pubmed-meshheading:9249576-... | lld:pubmed |
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| pubmed-article:9249576 | pubmed:meshHeading | pubmed-meshheading:9249576-... | lld:pubmed |
| pubmed-article:9249576 | pubmed:meshHeading | pubmed-meshheading:9249576-... | lld:pubmed |
| pubmed-article:9249576 | pubmed:meshHeading | pubmed-meshheading:9249576-... | lld:pubmed |
| pubmed-article:9249576 | pubmed:meshHeading | pubmed-meshheading:9249576-... | lld:pubmed |
| pubmed-article:9249576 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9249576 | pubmed:articleTitle | Acid stress induces a D1-like dopamine receptor in pituitary MSH cells of Oreochromis mossambicus. | lld:pubmed |
| pubmed-article:9249576 | pubmed:affiliation | Department of Animal Physiology, Faculty of Science, University of Nijmegen, The Netherlands. | lld:pubmed |
| pubmed-article:9249576 | pubmed:publicationType | Journal Article | lld:pubmed |
