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pubmed-article:9245726pubmed:dateCreated1997-9-15lld:pubmed
pubmed-article:9245726pubmed:abstractTextCnidarians are the lowest animal group having a nervous system. Using a radioimmunoassay for the C-terminal sequence Arg-Phe-NH2 (RFamide), we have isolated three novel neuropeptides from the jellyfish Cyanea lamarckii (belonging to the class Scyphozoa): (Glu-Trp-Leu-Arg-Gly-Arg-Phe-NH2 (Cyanea-RFamide I), (Glu-Pro-Leu-Trp-Ser-Gly-Arg-Phe-NH2 (Cyanea-RFamide II) and Gly-Arg-Phe-NH2 (Cyanea-RFamide III). The Cyanea-RFamides are neuropeptides and form a peptide family with other known neuropeptides isolated from Hydra and hydromedusae (belonging to the class Hydrozoa), and various sea anemones and sea pansies (belonging to the class Anthozoa). The presence of RFamide neuropeptides in all major cnidarian classes suggests that this type of substance was among the first neurotransmitters used in evolution.lld:pubmed
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pubmed-article:9245726pubmed:issn0006-291Xlld:pubmed
pubmed-article:9245726pubmed:authorpubmed-author:Grimmelikhuij...lld:pubmed
pubmed-article:9245726pubmed:authorpubmed-author:RinehartK LKLlld:pubmed
pubmed-article:9245726pubmed:authorpubmed-author:MooslerAAlld:pubmed
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pubmed-article:9245726pubmed:day30lld:pubmed
pubmed-article:9245726pubmed:volume236lld:pubmed
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pubmed-article:9245726pubmed:pagination743-9lld:pubmed
pubmed-article:9245726pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9245726pubmed:year1997lld:pubmed
pubmed-article:9245726pubmed:articleTitleIsolation of three novel neuropeptides, the Cyanea-RFamides I-III, from Scyphomedusae.lld:pubmed
pubmed-article:9245726pubmed:affiliationDepartment of Cell Biology and Anatomy, Zoological Institute, University of Copenhagen, Denmark.lld:pubmed
pubmed-article:9245726pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9245726pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9245726pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed