| pubmed-article:9242382 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C1519697 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9242382 | lifeskim:mentions | umls-concept:C1517488 | lld:lifeskim |
| pubmed-article:9242382 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9242382 | pubmed:dateCreated | 1997-8-21 | lld:pubmed |
| pubmed-article:9242382 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9242382 | pubmed:abstractText | Chromosome 6-mediated suppression of tumorigenicity in malignant melanoma cell lines provides a model system to identify genes associated with the reversion of the tumorigenic phenotype. Using subtractive cDNA selection, we recently identified a series of novel genes which are differentially expressed in association with chromosome 6-mediated suppression. We now report the molecular characterization of a novel gene termed AIM2 for (Absent In Melanoma), which represents a 1485 bp cDNA. An open reading frame of 1032 base pairs, corresponding to 344 amino acid residues, is predicted. The predicted protein shares a conserved sequence domain of approximately 200 amino acids with known interferon-inducible genes of both human and mouse. We demonstrate that the AIM2 gene encodes a transcript of approximately 2 kb which is expressed in spleen, small intestine, and peripheral blood leukocytes. In addition, we have localized AIM2 to the long arm of human chromosome 1 (band q22) in a highly conserved region which also contains the known interferon-inducible genes IFI16 and MNDA. We have also demonstrated that, like IFI16 and MNDA, AIM2 is induced in HL60 cells by interferon gamma. Our findings support the existence of a family of genes in this region similar to the well-characterized mouse Ifi200 gene family. | lld:pubmed |
| pubmed-article:9242382 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9242382 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9242382 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9242382 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9242382 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9242382 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:9242382 | pubmed:author | pubmed-author:RaoM KMK | lld:pubmed |
| pubmed-article:9242382 | pubmed:author | pubmed-author:TrentJ MJM | lld:pubmed |
| pubmed-article:9242382 | pubmed:author | pubmed-author:MeltzerP SPS | lld:pubmed |
| pubmed-article:9242382 | pubmed:author | pubmed-author:WuY MYM | lld:pubmed |
| pubmed-article:9242382 | pubmed:author | pubmed-author:JohnstoneR... | lld:pubmed |
| pubmed-article:9242382 | pubmed:author | pubmed-author:TrapaniJ AJA | lld:pubmed |
| pubmed-article:9242382 | pubmed:author | pubmed-author:AnzickS LSL | lld:pubmed |
| pubmed-article:9242382 | pubmed:author | pubmed-author:DeYoungK LKL | lld:pubmed |
| pubmed-article:9242382 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9242382 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9242382 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:9242382 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9242382 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9242382 | pubmed:pagination | 453-7 | lld:pubmed |
| pubmed-article:9242382 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9242382 | pubmed:meshHeading | pubmed-meshheading:9242382-... | lld:pubmed |
| pubmed-article:9242382 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9242382 | pubmed:articleTitle | Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. | lld:pubmed |
| pubmed-article:9242382 | pubmed:affiliation | Laboratory of Cancer Genetics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:9242382 | pubmed:publicationType | Journal Article | lld:pubmed |
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