| pubmed-article:9241726 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C0004461 | lld:lifeskim |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C1176472 | lld:lifeskim |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:9241726 | lifeskim:mentions | umls-concept:C0205374 | lld:lifeskim |
| pubmed-article:9241726 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9241726 | pubmed:dateCreated | 1997-10-1 | lld:pubmed |
| pubmed-article:9241726 | pubmed:abstractText | Two experiments were carried out to evaluate the relative contributions of thalamocortical and raphe-cortical fibers to the transient somatotopically organized pattern of serotonin (5-HT) immunoreactivity that appears in the primary somatosensory cortex (SI) of rats during the first 2 weeks of life. In the first experiment, the specific 5-HT uptake inhibitors, fluoxetine and paroxetine, were administered systemically, animals were killed 3, 6, or 12 h later, and cortices evaluated for 5-HT immunoreactivity. Fluoxetine treatment had no appreciable effect on the density of 5-HT immunoreactivity in the cortex. Paroxetine treatment caused a reduction in 5-HT immunoreactivity which was maximal 6 h after administration. Examination of the cortices of these animals revealed a loss of very fine dust-like 5-HT immunoreactivity, but a vibrissae-related pattern remained visible in thicker fibers. In a second experiment, raphe-cortical fibers were destroyed by systemic administration of 5,7-dihydroxytryptamine on the day of birth. Six days after this manipulation, 5-HT was applied directly to the cortex in vivo and the animals were then killed and cortices processed to demonstrate 5-HT immunoreactivity. The cortices of these rats revealed a fine dust-like immunoreactivity organized in a somatotopic pattern, but only very few 5-HT-positive axons. The results of these experiments suggest that both raphe-cortical axons and thalamocortical fibers contribute to the patterned 5-HT immunoreactivity observed in SI of perinatal rats. | lld:pubmed |
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| pubmed-article:9241726 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9241726 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9241726 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9241726 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9241726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9241726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9241726 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9241726 | pubmed:issn | 0899-0220 | lld:pubmed |
| pubmed-article:9241726 | pubmed:author | pubmed-author:RhoadesR WRW | lld:pubmed |
| pubmed-article:9241726 | pubmed:author | pubmed-author:ChiaiaN LNL | lld:pubmed |
| pubmed-article:9241726 | pubmed:author | pubmed-author:Bennett-Clark... | lld:pubmed |
| pubmed-article:9241726 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9241726 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:9241726 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9241726 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9241726 | pubmed:pagination | 27-33 | lld:pubmed |
| pubmed-article:9241726 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9241726 | pubmed:meshHeading | pubmed-meshheading:9241726-... | lld:pubmed |
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| pubmed-article:9241726 | pubmed:meshHeading | pubmed-meshheading:9241726-... | lld:pubmed |
| pubmed-article:9241726 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9241726 | pubmed:articleTitle | Contributions of raphe-cortical and thalamocortical axons to the transient somatotopic pattern of serotonin immunoreactivity in rat cortex. | lld:pubmed |
| pubmed-article:9241726 | pubmed:affiliation | Department of Anatomy and Neurobiology, Medical College of Ohio, Toledo 43699, USA. | lld:pubmed |
| pubmed-article:9241726 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9241726 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9241726 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9241726 | lld:pubmed |
