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pubmed-article:9236334pubmed:abstractTextAminooleic acid treatment has been demonstrated to prevent porcine valve calcification and to protect valvular hemodynamic function. Initial enthusiasm was tempered by histologic studies of these AOA valves, which showed cuspal hematomas, structural loosening, and surface roughening. This prompted a systematic review of the AOA treatment process. Unsolubilized particles of alpha aminooleic acid present in the treatment solution were identified as the cause of mechanical abrasion of valve cusps during processing. These particles were eliminated with a revamped protocol, which included filtration of the AOA solution before valve preparation.lld:pubmed
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pubmed-article:9236334pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9236334pubmed:articleTitleRefinement of the alpha aminooleic acid bioprosthetic valve anticalcification technique.lld:pubmed
pubmed-article:9236334pubmed:affiliationCarlyle Fraser Heart Center, Crawford Long Hospital of Emory University, Emory University School of Medicine, Atlanta, Georgia 30365, USA.lld:pubmed
pubmed-article:9236334pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9236334pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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