| pubmed-article:9234527 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9234527 | lifeskim:mentions | umls-concept:C0041296 | lld:lifeskim |
| pubmed-article:9234527 | lifeskim:mentions | umls-concept:C0032136 | lld:lifeskim |
| pubmed-article:9234527 | lifeskim:mentions | umls-concept:C0376613 | lld:lifeskim |
| pubmed-article:9234527 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:9234527 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:9234527 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
| pubmed-article:9234527 | pubmed:abstractText | Past attempts to use fractions of mycobacteria as an alternative to BCG have given disappointing results. The availability of cloned genes and suitable vectors has now opened a new avenue in which individual mycobacterial protein antigens are synthesised within transfected mammalian cells. In an ex vivo transfection approach with a retroviral vector we found that even a single antigen (hsp65) could evoke strong protection when expressed as a transgene and that expression of protection was largely a function of antigen specific cytotoxic T cells. We now find that intramuscular injection of plasmid DNA expressing the antigen from either a viral or a murine promoter can also give protection equivalent to Bacillus Calmette-Guérin (BCG). Plasmids expressing some other mycobacterial antigens, hsp70, 36 kDa and 6 kDa, are also effective, suggesting that this approach may lead to a new vaccine. | lld:pubmed |
| pubmed-article:9234527 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9234527 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9234527 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9234527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9234527 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9234527 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9234527 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:9234527 | pubmed:author | pubmed-author:LowrieD BDB | lld:pubmed |
| pubmed-article:9234527 | pubmed:author | pubmed-author:ColstonM JMJ | lld:pubmed |
| pubmed-article:9234527 | pubmed:author | pubmed-author:SilvaC LCL | lld:pubmed |
| pubmed-article:9234527 | pubmed:author | pubmed-author:TasconR ERE | lld:pubmed |
| pubmed-article:9234527 | pubmed:author | pubmed-author:RagnoSS | lld:pubmed |
| pubmed-article:9234527 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9234527 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:9234527 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9234527 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9234527 | pubmed:pagination | 834-8 | lld:pubmed |
| pubmed-article:9234527 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9234527 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9234527 | pubmed:articleTitle | Protection against tuberculosis by a plasmid DNA vaccine. | lld:pubmed |
| pubmed-article:9234527 | pubmed:affiliation | NIMR, London, UK. | lld:pubmed |
| pubmed-article:9234527 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9234527 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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