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| pubmed-article:9234269 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:9234269 | lifeskim:mentions | umls-concept:C1548779 | lld:lifeskim |
| pubmed-article:9234269 | lifeskim:mentions | umls-concept:C1947902 | lld:lifeskim |
| pubmed-article:9234269 | lifeskim:mentions | umls-concept:C2827499 | lld:lifeskim |
| pubmed-article:9234269 | lifeskim:mentions | umls-concept:C1550605 | lld:lifeskim |
| pubmed-article:9234269 | lifeskim:mentions | umls-concept:C0456205 | lld:lifeskim |
| pubmed-article:9234269 | lifeskim:mentions | umls-concept:C1167624 | lld:lifeskim |
| pubmed-article:9234269 | lifeskim:mentions | umls-concept:C1664784 | lld:lifeskim |
| pubmed-article:9234269 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9234269 | pubmed:dateCreated | 1997-9-25 | lld:pubmed |
| pubmed-article:9234269 | pubmed:abstractText | When injected intravenously, lipid vesicles labeled with 99mTc by means of a lipophilic chelator dipalmitoylphosphatidylethanolamine-diethylenetriaminetetraacetic acid (PE-DTTA) are rapidly accumulated by the mononuclear phagocytic system (MPS). By derivatizing the membrane surface with the lipid-polymer complex dipalmitoylphosphatidylethanolamine-monomethoxy polyethylene glycol 5000 (PE-MPEG), MPS uptake can be suppressed and loss of 99mTc label from the lipid surface reduced depending upon both PE-DTTA and PE-MPEG content. For vesicles containing 20% PE-DTTA, addition of PE-MPEG makes no difference to their rate of clearance from the circulation. However for vesicles containing 2% PE-DTTA, addition of more than 0.8% PE-MPEG increases circulation half-life, suppresses liver uptake and reduces renal clearance of the 99mTc label. The molar ratio of reducing agent (Sn) to chelator (PE-DTTA) is critical to efficient and reproducible labeling. For vesicles containing 2% PE-DTTA at a lipid concentration of 100 mM, a Sn/DTTA ratio of 0.35 gives close to optimal labeling. Variation in the Sn/DTTA ratio by a factor of two negatively impacts upon both labeling efficiency in vitro and circulation half-life in vivo. Potential uses for technetium-labeled lipid vesicles with extended circulation half-life are discussed. | lld:pubmed |
| pubmed-article:9234269 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9234269 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9234269 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9234269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9234269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9234269 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9234269 | pubmed:issn | 0969-8051 | lld:pubmed |
| pubmed-article:9234269 | pubmed:author | pubmed-author:FisherDD | lld:pubmed |
| pubmed-article:9234269 | pubmed:author | pubmed-author:AhkongQ FQF | lld:pubmed |
| pubmed-article:9234269 | pubmed:author | pubmed-author:TilcockCC | lld:pubmed |
| pubmed-article:9234269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9234269 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:9234269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9234269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9234269 | pubmed:pagination | 89-96 | lld:pubmed |
| pubmed-article:9234269 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9234269 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:9234269 | pubmed:articleTitle | 99mTc-labeling of lipid vesicles containing the lipophilic chelator PE-DTTA: effect of tin-to-chelate ratio, chelate content and surface polymer on labeling efficiency and biodistribution behavior. | lld:pubmed |
| pubmed-article:9234269 | pubmed:affiliation | Department of Radiology, University of British Columbia, Vancouver, Canada. | lld:pubmed |
| pubmed-article:9234269 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9234269 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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