pubmed-article:9233612 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
pubmed-article:9233612 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
pubmed-article:9233612 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:9233612 | pubmed:dateCreated | 1997-8-14 | lld:pubmed |
pubmed-article:9233612 | pubmed:abstractText | We previously showed that T cells from the mediastinal lymph nodes (MLN) and lung parenchyma of influenza virus-infected mice were functionally remarkably different. Here we demonstrate that the differences in cytokine production are due to differences in the frequencies of T cells within the activated pool able to produce cytokines after TCR stimulation. FACS analysis of T cells from MLN and lung tissue demonstrated that T cells expressing any of the activation markers tested (LFA-1, CD25, CD44, CD45RB, CD49d, CD62L) always expressed high levels of CD44 and LFA-1. These double-high T cells produced >99% of all anti-CD3 mAb-induced IL-4 and IFN-gamma. Separation of T cells employing mAb against the other activation markers in combination with anti-CD44 mAb did not enable further fractionation into cytokine producers and nonproducers. Despite their similar phenotype, purified double-high lung parenchyma T cells produced markedly higher levels of IL-2, IL-4, and IFN-gamma, and contained a higher frequency of cytokine producers than their MLN counterparts. Activation of the extracellular signal-regulated kinase (ERK)-2 in response to TCR cross-linking was detected in double-high T cells from lung tissue but not MLN. The requirement for ERK signaling for maximal IFN-gamma synthesis could nevertheless be demonstrated in both populations by blockade with the inhibitor PD98509. Collectively, the data suggest that inductive and effector sites differ in the frequency of activated T cells able to induce ERK-2-regulated cytokine production after TCR ligation. | lld:pubmed |
pubmed-article:9233612 | pubmed:language | eng | lld:pubmed |
pubmed-article:9233612 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9233612 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:9233612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9233612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:9233612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9233612 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9233612 | pubmed:month | Aug | lld:pubmed |
pubmed-article:9233612 | pubmed:issn | 0022-1767 | lld:pubmed |
pubmed-article:9233612 | pubmed:author | pubmed-author:KelsoAA | lld:pubmed |
pubmed-article:9233612 | pubmed:author | pubmed-author:EgertonMM | lld:pubmed |
pubmed-article:9233612 | pubmed:author | pubmed-author:BaumgarthNN | lld:pubmed |
pubmed-article:9233612 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9233612 | pubmed:day | 1 | lld:pubmed |
pubmed-article:9233612 | pubmed:volume | 159 | lld:pubmed |
pubmed-article:9233612 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9233612 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9233612 | pubmed:pagination | 1182-91 | lld:pubmed |
pubmed-article:9233612 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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pubmed-article:9233612 | pubmed:year | 1997 | lld:pubmed |
pubmed-article:9233612 | pubmed:articleTitle | Activated T cells from draining lymph nodes and an effector site differ in their responses to TCR stimulation. | lld:pubmed |
pubmed-article:9233612 | pubmed:affiliation | Cooperative Research Center for Vaccine Technology, Queensland Institute of Medical Research, Brisbane, Australia. Baumgarth@Darwin.Stanford.edu | lld:pubmed |
pubmed-article:9233612 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9233612 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:9233612 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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