| pubmed-article:9228526 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C1136140 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:9228526 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:9228526 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9228526 | pubmed:dateCreated | 1997-9-9 | lld:pubmed |
| pubmed-article:9228526 | pubmed:abstractText | Long-term depression (LTD) of synaptic strength is induced by glutamate-triggered increases in postsynaptic [Ca2+], through either influx or release from intracellular stores. Induction of LTD has also been reported to require release of Ca2+ from presynaptic stores and activation of presynaptic Ca2+/calmodulin-dependent protein kinase II. This finding leads to the hypothesis that the intercellular messenger nitric oxide (NO) may be a means by which postsynaptic Ca2+ triggers changes expressing LTD in presynaptic terminals. We report that bath application of the oxadiazoloquinoxalone derivative ODQ (4 microM), a selective inhibitor of NO-sensitive guanylyl cyclase (NOGC), markedly attenuated (90%) the magnitude of LTD induced by low-frequency stimulation (LFS; 1 Hz/15 min) of Schaffer collateral-CA1 synapses in hippocampal slices in vitro. Both the NO donor S-nitroso-N-acetylpenicillamine (100 microM) and the membrane-permeant cyclic guanine 3',5'-monophosphate (cGMP) analogue 8-(-4-chlorophenylthio) guanosine (8-pCPT)-cGMP (50 microM) enhanced the magnitude of LTD, which is consistent with he hypothesis that activation of NOGC plays a role in the induction of LTD. Nicotinamide (20 mM), an inhibitor of NO-activated ADP ribosyltransferase, did not impair the induction of LTD. In contrast to de novo LTD, the reversal of long-term potentiation by LFS (depotentiation) was only partially blocked (55%) by ODQ, and heterosynaptic LTD was not impaired at all, suggesting that there are both NOGC-dependent and -independent forms of LTD. Because postsynaptic intracellular infusion of ODQ (500 microM) failed to block the induction of LTD, we conclude that activation of presynaptic NOGC is a necessary step in the induction of an NOGC-dependent component of LTD. | lld:pubmed |
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| pubmed-article:9228526 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9228526 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9228526 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9228526 | pubmed:issn | 1050-9631 | lld:pubmed |
| pubmed-article:9228526 | pubmed:author | pubmed-author:ReyesMM | lld:pubmed |
| pubmed-article:9228526 | pubmed:author | pubmed-author:StantonP KPK | lld:pubmed |
| pubmed-article:9228526 | pubmed:author | pubmed-author:GageA TAT | lld:pubmed |
| pubmed-article:9228526 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9228526 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:9228526 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9228526 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9228526 | pubmed:pagination | 286-95 | lld:pubmed |
| pubmed-article:9228526 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9228526 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9228526 | pubmed:articleTitle | Nitric-oxide-guanylyl-cyclase-dependent and -independent components of multiple forms of long-term synaptic depression. | lld:pubmed |
| pubmed-article:9228526 | pubmed:affiliation | Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461-1602, USA. | lld:pubmed |
| pubmed-article:9228526 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9228526 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9228526 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9228526 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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