| pubmed-article:9221938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0162783 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0205098 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0016904 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0022614 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:9221938 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:9221938 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9221938 | pubmed:dateCreated | 1997-10-28 | lld:pubmed |
| pubmed-article:9221938 | pubmed:abstractText | Cognitive functions regulated by the prefrontal cortex are sensitive to changes in dopaminergic and serotoninergic transmission. The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine influences dopaminergic transmission and induces psychotic symptoms in normal and schizophrenic individuals. This study examined the effect of single and repeated ketamine (25 mg/kg, i.p.) administration on extracellular levels of dopamine, GABA and the serotonin metabolite 5-hydroxyindoleacetic (5-HIAA) acid in the medial prefrontal cortex using in vivo microdialysis in conscious rat. In line with earlier studies, we observed a transient five-fold increase in dopamine release following single ketamine administration in drug naive animals. However, we also observed a two-fold increase in basal dopamine levels and an almost complete attenuation of the ketamine-induced increase in dopamine release in animals pre-treated with ketamine once daily for 7 days. Extracellular 5-HIAA levels were increased by ketamine in both drug naive and even more enhanced in ketamine-pre-treated animals but without a change in basal 5-HIAA levels. GABA levels were unaffected by either single or repeated ketamine administration. We demonstrate evidence for a differential effect of single and repeated ketamine administration on dopamine, serotonin and GABA transmission in the medial prefrontal cortex. We provide new evidence for a complex adaptation of neurotransmission following repeated NMDA receptor blockade whereby in the presence of increased basal dopamine levels the ketamine-induced increase in dopamine is attenuated and the increase in 5-HIAA is enhanced. It appears from our results that ketamine pre-treatment reduces the dynamics of dopaminergic transmission in the prefrontal cortex and may possibly alter the balance between dopamine and serotonin transmission. | lld:pubmed |
| pubmed-article:9221938 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9221938 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221938 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9221938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9221938 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9221938 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:9221938 | pubmed:author | pubmed-author:LindeforsNN | lld:pubmed |
| pubmed-article:9221938 | pubmed:author | pubmed-author:O'ConnorW TWT | lld:pubmed |
| pubmed-article:9221938 | pubmed:author | pubmed-author:BaratzDD | lld:pubmed |
| pubmed-article:9221938 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9221938 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:9221938 | pubmed:volume | 759 | lld:pubmed |
| pubmed-article:9221938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9221938 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9221938 | pubmed:pagination | 205-12 | lld:pubmed |
| pubmed-article:9221938 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:meshHeading | pubmed-meshheading:9221938-... | lld:pubmed |
| pubmed-article:9221938 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9221938 | pubmed:articleTitle | Differential effects of single and repeated ketamine administration on dopamine, serotonin and GABA transmission in rat medial prefrontal cortex. | lld:pubmed |
| pubmed-article:9221938 | pubmed:affiliation | Department of Clinical Neuroscience, Karolinska Institutet and Hospital, Stockholm, Sweden. nilsl@psyk.ks.se | lld:pubmed |
| pubmed-article:9221938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9221938 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9221938 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9221938 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9221938 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9221938 | lld:pubmed |
