| pubmed-article:9221811 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C1618608 | lld:lifeskim |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C1334522 | lld:lifeskim |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C1417203 | lld:lifeskim |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9221811 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9221811 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9221811 | pubmed:dateCreated | 1997-7-24 | lld:pubmed |
| pubmed-article:9221811 | pubmed:abstractText | Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a presumed activator of MMP2, which is one of the major proteinases in tumor cell invasion. In this study, we determined the clinico-pathologic significance of MT1-MMP expression in 68 human gastric carcinomas. The tumor-normal ratio (T/N ratio) of MTI-MMP expression was determined by reverse transcription-polymerase chain reaction analysis. To visualize the localization of MT1-MMP, an immunohistochemical study was performed. In addition, a gelatin zymography was done to examine the activation ratio of MMP2, and a correlation between MT1-MMP expression and activation of MMP2 was studied. The expression of MT1-MMP mRNA was higher in tumor tissue than in corresponding normal tissue in most cases. The mean value of the T/N ratio was 4.8. Twenty cases with T/N > or = 4.8 showed significantly deeper invasion and higher frequency of lymph node metastasis than 48 cases with T/N < 4.8. MT1-MMP expression was an independent factor influencing both tumor invasion of the gastric wall and lymph node metastasis. Although MT1-MMP expression was not an independent prognostic factor, the patients with T/N > or = 4.8 showed a significantly worse prognosis than those with T/N < 4.8. An immunohistochemical study demonstrated that MT1-MMP expression was mainly recognized in the tumor cells. There was a significant correlation between MT1-MMP expression and activation of MMP2. Our findings suggest that: 1) the expression of MT1-MMP may influence prognosis via tumor invasion of the gastric wall and lymph node metastasis, and 2) MT1-MMP activation of MMP2 may be clinically relevant in gastric carcinoma tumors. | lld:pubmed |
| pubmed-article:9221811 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9221811 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221811 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9221811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9221811 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9221811 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9221811 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:MoriMM | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:ShiraishiTT | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:BabaKK | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:FujieTT | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:AkiyoshiTT | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:KusumotoHH | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:UeoHH | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:HaraguchiMM | lld:pubmed |
| pubmed-article:9221811 | pubmed:author | pubmed-author:MimoriKK | lld:pubmed |
| pubmed-article:9221811 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9221811 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:9221811 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:9221811 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9221811 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9221811 | pubmed:pagination | 316-21 | lld:pubmed |
| pubmed-article:9221811 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
| pubmed-article:9221811 | pubmed:meshHeading | pubmed-meshheading:9221811-... | lld:pubmed |
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| pubmed-article:9221811 | pubmed:meshHeading | pubmed-meshheading:9221811-... | lld:pubmed |
| pubmed-article:9221811 | pubmed:meshHeading | pubmed-meshheading:9221811-... | lld:pubmed |
| pubmed-article:9221811 | pubmed:meshHeading | pubmed-meshheading:9221811-... | lld:pubmed |
| pubmed-article:9221811 | pubmed:meshHeading | pubmed-meshheading:9221811-... | lld:pubmed |
| pubmed-article:9221811 | pubmed:meshHeading | pubmed-meshheading:9221811-... | lld:pubmed |
| pubmed-article:9221811 | pubmed:meshHeading | pubmed-meshheading:9221811-... | lld:pubmed |
| pubmed-article:9221811 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9221811 | pubmed:articleTitle | Analysis of MT1-MMP and MMP2 expression in human gastric cancers. | lld:pubmed |
| pubmed-article:9221811 | pubmed:affiliation | Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan. | lld:pubmed |
| pubmed-article:9221811 | pubmed:publicationType | Journal Article | lld:pubmed |
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