| pubmed-article:9218735 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9218735 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9218735 | lifeskim:mentions | umls-concept:C0338106 | lld:lifeskim |
| pubmed-article:9218735 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:9218735 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:9218735 | lifeskim:mentions | umls-concept:C0013089 | lld:lifeskim |
| pubmed-article:9218735 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:9218735 | lifeskim:mentions | umls-concept:C0205132 | lld:lifeskim |
| pubmed-article:9218735 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9218735 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9218735 | pubmed:dateCreated | 1997-7-29 | lld:pubmed |
| pubmed-article:9218735 | pubmed:abstractText | Intrinsic low-level resistance to anti-cancer drugs is a major problem in the treatment of gastrointestinal malignancies. To address the problem presented by intrinsically resistant tumours, we have isolated two monoclonal lines from LoVo human colon adenocarcinoma cells: LoVo/C7, which is intrinsically resistant to doxorubicin (DOX); and LoVo/C5, which shows the same resistance index for DOX as the mixed parental cell population. For comparison, we have included in the study a LoVo-resistant line selected by continuous exposure to DOX and expressing a typical multidrug resistant (MDR) phenotype. In these cell lines we have studied the expression and/or activity of a number of proteins, including P-glycoprotein 170 (P-gp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), glutathione (GSH)-dependent enzymes and protein kinase C (PKC) isoforms, which have been implicated in anti-cancer drug resistance. Intracellular DOX distribution has been assessed by confocal microscopy. The results of the present study indicate that resistance in LoVo/C7 cells cannot be attributed to alterations in P-gp, LRP or GSH/GSH-dependent enzyme levels. Increased expression of MRP, accompanied by alterations in the subcellular distribution of DOX, has been observed in LoVo/C7 cells; changes in PKC isoform pattern have been detected in both intrinsically and pharmacologically resistant cells. | lld:pubmed |
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| pubmed-article:9218735 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9218735 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9218735 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9218735 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9218735 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:DolfiniEE | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:ScheperR JRJ | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:MolinariAA | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:DasdiaTT | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:AranciaGG | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:MontiEE | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:FlensM JMJ | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:CalcabriniAA | lld:pubmed |
| pubmed-article:9218735 | pubmed:author | pubmed-author:GariboldiM... | lld:pubmed |
| pubmed-article:9218735 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9218735 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:9218735 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9218735 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9218735 | pubmed:pagination | 67-76 | lld:pubmed |
| pubmed-article:9218735 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9218735 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9218735 | pubmed:articleTitle | Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin. | lld:pubmed |
| pubmed-article:9218735 | pubmed:affiliation | Department of Biology and Genetics for Health Sciences, University of Milano, Milan, Italy. | lld:pubmed |
| pubmed-article:9218735 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9218735 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9218735 | lld:pubmed |
