pubmed-article:9218482 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C0031760 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C0018338 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C0031640 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
pubmed-article:9218482 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
pubmed-article:9218482 | pubmed:issue | 29 | lld:pubmed |
pubmed-article:9218482 | pubmed:dateCreated | 1997-8-18 | lld:pubmed |
pubmed-article:9218482 | pubmed:abstractText | The cGMP phosphodiesterase from retinal rods (PDE-6) is an alphabetagamma2 heterotetramer. The alpha and beta subunits contain catalytic sites for cGMP hydrolysis, whereas the gamma subunits serve as a protein inhibitor of the enzyme. Visual excitation of photoreceptors enables the activated GTP-bound form of the G-protein transducin to remove the inhibitory action of the gamma subunit, thereby triggering PDE-6 activation. The type 5 phosphodiesterase (PDE-5) isoform shares a number of similar characteristics with PDE-6, including binding of cGMP to noncatalytic sites, the cyclic nucleotide specificity, and inhibitor sensitivities. Although the functional role of PDE-5 remains unclear, it has been shown to be activated by protein kinase A (PKA) (Burns, F., Rodger, I. W. & Pyne, N. J. (1992) Biochem. J. 283, 487-491). Here we report that both the recombinant gamma subunit and a peptide corresponding to amino acids 24-46 in this protein inhibited the activation of PDE-5 by PKA. Furthermore, immunoblotting airway smooth muscle membranes with a specific antibody against amino acids 24-46 of the PDE-6 gamma subunit identified two major immunoreactive small molecular mass proteins of 14 and 18 kDa (p14 and p18). These appear to form a complex with PDE-5, because PDE activity was immunoprecipitated using antibody against the PDE-6 gamma subunit. p14 and p18 were also substrates for phosphorylation by a unidentified kinase that was stimulated by a pertussis toxin-sensitive G-protein. Phosphorylation of p14/p18 in membranes treated with guanine nucleotides correlated with a concurrent reduction in the activation of PDE-5 by PKA. We suggest that p14 and p18 share an epitope common to PDE-6 gamma and that this region may interact with PDE-5 to prevent its activation by PKA. | lld:pubmed |
pubmed-article:9218482 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:language | eng | lld:pubmed |
pubmed-article:9218482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9218482 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9218482 | pubmed:month | Jul | lld:pubmed |
pubmed-article:9218482 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:9218482 | pubmed:author | pubmed-author:PyneN JNJ | lld:pubmed |
pubmed-article:9218482 | pubmed:author | pubmed-author:ArshavskyV... | lld:pubmed |
pubmed-article:9218482 | pubmed:author | pubmed-author:LochheadAA | lld:pubmed |
pubmed-article:9218482 | pubmed:author | pubmed-author:NekrasovaEE | lld:pubmed |
pubmed-article:9218482 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9218482 | pubmed:day | 18 | lld:pubmed |
pubmed-article:9218482 | pubmed:volume | 272 | lld:pubmed |
pubmed-article:9218482 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9218482 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9218482 | pubmed:pagination | 18397-403 | lld:pubmed |
pubmed-article:9218482 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:9218482 | pubmed:year | 1997 | lld:pubmed |
pubmed-article:9218482 | pubmed:articleTitle | The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. | lld:pubmed |
pubmed-article:9218482 | pubmed:affiliation | Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G1 1XW, Scotland. | lld:pubmed |
pubmed-article:9218482 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9218482 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:9218482 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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