| pubmed-article:9216985 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0051318 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0870432 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C1705417 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C1555465 | lld:lifeskim |
| pubmed-article:9216985 | lifeskim:mentions | umls-concept:C0205812 | lld:lifeskim |
| pubmed-article:9216985 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9216985 | pubmed:dateCreated | 1997-9-2 | lld:pubmed |
| pubmed-article:9216985 | pubmed:abstractText | A minority subset of cortical neurones exhibit kainate-activated Co2+ uptake, a marker for AMPA/kainate receptor gated Ca2+-permeable channels. Consistent with enhanced Ca2+ influx through these channels, Co2+-positive neurones are unusually vulnerable to death induced by exposure to either AMPA or kainate. Here we show that Co2+-positive cortical neurones express a distinctive profile of AMPA receptor subunits as determined by immunostaining. Co2+-positive neurones were much less likely to express GluR2/GluR3, and much more likely to express GluR1 or GluR4, than the general cortical neuronal population. Thus expression of AMPA receptors lacking the GluR2 subunit may explain the Co2+ staining, and selective vulnerability to kainate exhibited by Co2+-positive cells. Almost all GABAergic neurones, identified by immunostaining for glutamic acid decarboxylase, were Co2+-positive. The widespread presence of Ca2+-permeable AMPA/kainate receptor-gated channels on cortical GABAergic neurones may have important implications for the fate of cortical inhibition in disease states associated with the excitotoxic overstimulation of glutamate receptors. | lld:pubmed |
| pubmed-article:9216985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9216985 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9216985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9216985 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9216985 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9216985 | pubmed:issn | 0969-9961 | lld:pubmed |
| pubmed-article:9216985 | pubmed:author | pubmed-author:WeissJ HJH | lld:pubmed |
| pubmed-article:9216985 | pubmed:author | pubmed-author:CohnN HNH | lld:pubmed |
| pubmed-article:9216985 | pubmed:author | pubmed-author:YomH CHC | lld:pubmed |
| pubmed-article:9216985 | pubmed:author | pubmed-author:TuretskyDD | lld:pubmed |
| pubmed-article:9216985 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9216985 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:9216985 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9216985 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9216985 | pubmed:pagination | 43-9 | lld:pubmed |
| pubmed-article:9216985 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
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| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:meshHeading | pubmed-meshheading:9216985-... | lld:pubmed |
| pubmed-article:9216985 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:9216985 | pubmed:articleTitle | Cortical neurones with Ca2+ permeable AMPA/kainate channels display distinct receptor immunoreactivity and are GABAergic. | lld:pubmed |
| pubmed-article:9216985 | pubmed:affiliation | Department of Neurology, University of California Irvine, Irvine, California 92717-4290, USA. | lld:pubmed |
| pubmed-article:9216985 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9216985 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9216985 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9216985 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9216985 | lld:pubmed |
