| pubmed-article:9212736 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9212736 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9212736 | lifeskim:mentions | umls-concept:C0024296 | lld:lifeskim |
| pubmed-article:9212736 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:9212736 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:9212736 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:9212736 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9212736 | lifeskim:mentions | umls-concept:C1416961 | lld:lifeskim |
| pubmed-article:9212736 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:9212736 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9212736 | pubmed:dateCreated | 1997-7-31 | lld:pubmed |
| pubmed-article:9212736 | pubmed:abstractText | Lymphocyte homing to normal tissues and recruitment to inflammatory tissue sites are controlled, in part, by the selective expression of chemokines, pro-inflammatory cytokines and mediators, and various adhesion proteins and molecules. In the mouse, mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is selectively expressed on endothelium of high endothelial venules in gut and gut-associated lymphoid tissue. By interaction with its integrin ligand, alpha 4 beta 7, lymphocytes presumed to be involved in mucosal immunity are selectively recruited to these intestinal sites. After generating monoclonal antibodies against a murine cell line expressing recombinant human MAdCAM-1, we qualitatively and semiquantitatively assessed MAdCAM-1 expression in human tissue sections from various normal and inflammatory disorders. We found that human MAdCAM-1, as in the mouse, is expressed in a tissue-selective manner. In normal tissues, MAdCAM-1 is constitutively expressed to endothelium of venules of intestinal lamina propria. Interestingly, using computer-assisted morphometric analysis, the proportion of venular endothelium within lamina propria that expresses MAdCAM-1 is increased, compared with normal tissues, at inflammatory foci associated with ulcerative colitis and Crohn's disease. Moreover, for the most part, MAdCAM-1 is not detected in the majority of normal or inflamed extra-intestinal tissues, including those with mucosal surfaces. These results are consistent with a role, as originally defined in the mouse, for human MAdCAM-1 in the localization of alpha 4 beta 7+ lymphocytes in the gastrointestinal tract and associated lymphoid tissue. As such, the pathway defined by MAdCAM-1/alpha 4 beta 7 may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity. | lld:pubmed |
| pubmed-article:9212736 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9212736 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9212736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9212736 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9212736 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9212736 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:WilsonJJ | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:ButcherE CEC | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:BloomSS | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:NewmanWW | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:CochranNN | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:RinglerD JDJ | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:MackayC RCR | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:McEvoyL MLM | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:KassamNN | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:BriskinMM | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:Winsor-HinesD... | lld:pubmed |
| pubmed-article:9212736 | pubmed:author | pubmed-author:ShyjanAA | lld:pubmed |
| pubmed-article:9212736 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9212736 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:9212736 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9212736 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9212736 | pubmed:pagination | 97-110 | lld:pubmed |
| pubmed-article:9212736 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:meshHeading | pubmed-meshheading:9212736-... | lld:pubmed |
| pubmed-article:9212736 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9212736 | pubmed:articleTitle | Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. | lld:pubmed |
