| pubmed-article:9210401 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0007745 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0029282 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9210401 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9210401 | pubmed:dateCreated | 1997-7-28 | lld:pubmed |
| pubmed-article:9210401 | pubmed:abstractText | Ceramide has emerged as a novel lipid mediator in cell growth and apoptosis. In difluoromethylornithine-resistant L1210 cells stimulated to growth from quiescence, the cell-permeant analogues of ceramide N-acetylsphingosine (C2-ceramide) and N-hexanoylsphingosine (C6-ceramide) inhibited the induction of ornithine decarboxylase (ODC) activity with IC50 of 8.3 and 1.5 microM respectively. This effect was strictly related to the ability to inhibit cell growth and [3H]thymidine incorporation. The suppression of cell growth was also associated with apoptosis. The addition of bacterial sphingomyelinase resulted in a significant, but limited, reduction of ODC induction and [3H]thymidine incorporation. Bacterial lipopolysaccharide, which may act as a ceramide analogue, also inhibited the induction of the enzyme. Moreover, C6-ceramide largely prevented the accumulation of ODC mRNA and its precursor, ODC heterogeneous nuclear RNA, that accompanied the induction of ODC activity. A slight increase in ODC turnover was also observed. The DNA-binding activity of some transcription factors known to bind and transactivate the ODC gene was investigated by gel mobility-shift assay under the same experimental conditions. However, only the binding of Myc/Max was negatively affected by the treatment with C6-ceramide. Furthermore, the amount of immunoreactive c-Myc, which increased after stimulation of the cells to growth, was strongly reduced by C6-ceramide. These results suggest that the inhibition of c-Myc and ODC expression may be early events in the response of leukaemia cells to ceramide. | lld:pubmed |
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| pubmed-article:9210401 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9210401 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9210401 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9210401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9210401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9210401 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9210401 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9210401 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:9210401 | pubmed:author | pubmed-author:RossoniCC | lld:pubmed |
| pubmed-article:9210401 | pubmed:author | pubmed-author:FlamigniFF | lld:pubmed |
| pubmed-article:9210401 | pubmed:author | pubmed-author:MuscariCC | lld:pubmed |
| pubmed-article:9210401 | pubmed:author | pubmed-author:StefanelliCC | lld:pubmed |
| pubmed-article:9210401 | pubmed:author | pubmed-author:GiaccariAA | lld:pubmed |
| pubmed-article:9210401 | pubmed:author | pubmed-author:MarmiroliSS | lld:pubmed |
| pubmed-article:9210401 | pubmed:author | pubmed-author:FaenzaII | lld:pubmed |
| pubmed-article:9210401 | pubmed:author | pubmed-author:Stanic'II | lld:pubmed |
| pubmed-article:9210401 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9210401 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9210401 | pubmed:volume | 324 ( Pt 3) | lld:pubmed |
| pubmed-article:9210401 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9210401 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9210401 | pubmed:pagination | 783-9 | lld:pubmed |
| pubmed-article:9210401 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
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| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
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| pubmed-article:9210401 | pubmed:meshHeading | pubmed-meshheading:9210401-... | lld:pubmed |
| pubmed-article:9210401 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9210401 | pubmed:articleTitle | Inhibition of the expression of ornithine decarboxylase and c-Myc by cell-permeant ceramide in difluoromethylornithine-resistant leukaemia cells. | lld:pubmed |
| pubmed-article:9210401 | pubmed:affiliation | Dipartimento di Biochimica 'G.Moruzzi', Università di Bologna, via Irnerio 48, 40126 Bologna, Italy. | lld:pubmed |
| pubmed-article:9210401 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9210401 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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