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pubmed-article:9199822pubmed:dateCreated1997-9-4lld:pubmed
pubmed-article:9199822pubmed:abstractTextFactor V antigen levels were measured in 40 patients with factor V deficiency (11 homozygous and 29 heterozygous), in 38 patients with factor V Leiden mutation (16 homozygous and 22 heterozygous) and in three patients with combined heterozygous factor V deficiency and heterozygous factor V Leiden mutation (so-called pseudohomozygosis for APC resistance). Twenty normal subjects of both sexes served as controls. Factor V antigen levels compared well with factor V activity in normal subjects and in all groups of patients. They were normal both in homozygous and heterozygous APC resistance patients. Factor V antigen determination may be useful for the diagnosis of pseudohomozygosis for APC resistance. These patients have a phenotypic picture similar to homozygous APC resistance, but show a factor V antigen level about half the normal value since they are compound heterozygotes for factor V deficiency and APC resistance. In contrast, homozygous patients for APC resistance show normal factor V activity and antigen levels.lld:pubmed
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pubmed-article:9199822pubmed:authorpubmed-author:GirolamiAAlld:pubmed
pubmed-article:9199822pubmed:authorpubmed-author:SimioniPPlld:pubmed
pubmed-article:9199822pubmed:authorpubmed-author:ZanonEElld:pubmed
pubmed-article:9199822pubmed:authorpubmed-author:GirolamiBBlld:pubmed
pubmed-article:9199822pubmed:authorpubmed-author:VenturelliUUlld:pubmed
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pubmed-article:9199822pubmed:volume8lld:pubmed
pubmed-article:9199822pubmed:ownerNLMlld:pubmed
pubmed-article:9199822pubmed:authorsCompleteYlld:pubmed
pubmed-article:9199822pubmed:pagination245-8lld:pubmed
pubmed-article:9199822pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:9199822pubmed:year1997lld:pubmed
pubmed-article:9199822pubmed:articleTitleFactor V antigen levels in APC resistance, in factor V deficiency and in combined APC resistance and factor V deficiency (pseudohomozygosis for APC resistance).lld:pubmed
pubmed-article:9199822pubmed:affiliationUniversity of Padua Medical School, Institute of Medical Semeiotics, Padua, Italy.lld:pubmed
pubmed-article:9199822pubmed:publicationTypeJournal Articlelld:pubmed