| pubmed-article:9194690 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9194690 | lifeskim:mentions | umls-concept:C0025815 | lld:lifeskim |
| pubmed-article:9194690 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:9194690 | lifeskim:mentions | umls-concept:C0007582 | lld:lifeskim |
| pubmed-article:9194690 | lifeskim:mentions | umls-concept:C0806140 | lld:lifeskim |
| pubmed-article:9194690 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9194690 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:9194690 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:9194690 | pubmed:dateCreated | 1997-7-17 | lld:pubmed |
| pubmed-article:9194690 | pubmed:abstractText | The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system. Human neutrophilic polymorphonuclear leukocytes (PMN) were perfused at a shear stress of 1 dyne/cm2 on human umbilical vein endothelial cells (HUVEC) pretreated with IL-1beta (20 U/mL) for 4 hours. Many PMN adhered to IL-1-stimulated HUVEC and then migrated beneath endothelial cell monolayers. Treatment of HUVEC with m-PSL inhibited adherence and migration of PMN in a dose dependent manner. M-PSL also inhibited IL-1beta-induced upregulation of E-selectin and ICAM-1 on HUVEC in a dose dependent manner. These results suggest that m-PSL works as an anti-inflammatory agent through inhibiting PMN-endothelial cell interactions. | lld:pubmed |
| pubmed-article:9194690 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9194690 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9194690 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9194690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9194690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9194690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9194690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9194690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9194690 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9194690 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:9194690 | pubmed:author | pubmed-author:SakamotoKK | lld:pubmed |
| pubmed-article:9194690 | pubmed:author | pubmed-author:YoshidaNN | lld:pubmed |
| pubmed-article:9194690 | pubmed:author | pubmed-author:ManabeHH | lld:pubmed |
| pubmed-article:9194690 | pubmed:author | pubmed-author:NakamuraYY | lld:pubmed |
| pubmed-article:9194690 | pubmed:author | pubmed-author:KondoMM | lld:pubmed |
| pubmed-article:9194690 | pubmed:author | pubmed-author:NakagawaSS | lld:pubmed |
| pubmed-article:9194690 | pubmed:author | pubmed-author:YoshikawaTT | lld:pubmed |
| pubmed-article:9194690 | pubmed:author | pubmed-author:TakenakaSS | lld:pubmed |
| pubmed-article:9194690 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9194690 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:9194690 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9194690 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9194690 | pubmed:pagination | 2341-7 | lld:pubmed |
| pubmed-article:9194690 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:meshHeading | pubmed-meshheading:9194690-... | lld:pubmed |
| pubmed-article:9194690 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9194690 | pubmed:articleTitle | Methylprednisolone inhibits neutrophil-endothelial cell interactions induced by interleukin-1beta under flow conditions. | lld:pubmed |
| pubmed-article:9194690 | pubmed:affiliation | First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Japan. | lld:pubmed |
| pubmed-article:9194690 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9194690 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9194690 | lld:pubmed |
