| pubmed-article:9192772 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9192772 | lifeskim:mentions | umls-concept:C0006413 | lld:lifeskim |
| pubmed-article:9192772 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:9192772 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:9192772 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:9192772 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9192772 | pubmed:dateCreated | 1997-7-10 | lld:pubmed |
| pubmed-article:9192772 | pubmed:abstractText | Bcl-2 is an oncogene that confers deregulated growth potential to B lymphocytes through its ability to inhibit apoptotic cell death. A specific molecular activity for the Bcl-2 protein has not been identified, but several lines of evidence have supported a role in protection of cells from oxidative stress. We investigated whether there is a correlation between expression of high levels of Bcl-2 and susceptibility of human Burkitt's lymphoma cell lines to H2O2-induced killing. The amount of H2O2 required to kill 50% of cells in 24 hours varied widely in the seven different lymphoma cell lines that were tested, ranging from 35 to 500 micromol/L H2O2. However, expression of high levels of endogenous Bcl-2 did not protect the cells from H2O2-induced killing, even though it was effective in protecting the cells from apoptosis induced by agents such as A23187. Thus, Bcl-2 was functional in preventing apoptosis but did not act in an antioxidant capacity. The results were confirmed using a Burkitt's lymphoma cell line overexpressing transfected bcl-2. The results may be explained by the observation that H2O2 was inefficient at inducing apoptosis in these mature B-cell lines. Nonapoptotic death induced by H2O2 was not prevented by Bcl-2. | lld:pubmed |
| pubmed-article:9192772 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9192772 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192772 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9192772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192772 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9192772 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9192772 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:9192772 | pubmed:author | pubmed-author:LeoCC | lld:pubmed |
| pubmed-article:9192772 | pubmed:author | pubmed-author:ShacterEE | lld:pubmed |
| pubmed-article:9192772 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9192772 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9192772 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:9192772 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9192772 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9192772 | pubmed:pagination | 4480-92 | lld:pubmed |
| pubmed-article:9192772 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9192772 | pubmed:meshHeading | pubmed-meshheading:9192772-... | lld:pubmed |
| pubmed-article:9192772 | pubmed:meshHeading | pubmed-meshheading:9192772-... | lld:pubmed |
| pubmed-article:9192772 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9192772 | pubmed:articleTitle | Bcl-2 does not protect Burkitt's lymphoma cells from oxidant-induced cell death. | lld:pubmed |
| pubmed-article:9192772 | pubmed:affiliation | Laboratory of Immunology, Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892-4555, USA. | lld:pubmed |
| pubmed-article:9192772 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9192772 | pubmed:publicationType | Comparative Study | lld:pubmed |
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