| pubmed-article:9188629 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0026626 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C1706515 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C1704640 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0079866 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0599814 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:9188629 | lifeskim:mentions | umls-concept:C0331858 | lld:lifeskim |
| pubmed-article:9188629 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9188629 | pubmed:dateCreated | 1997-7-10 | lld:pubmed |
| pubmed-article:9188629 | pubmed:abstractText | We have created two sets of substitution mutations in the Moloney murine leukemia virus (Mo-MuLV) matrix protein in order to identify domains involved in association with the plasma membrane and in incorporation of the viral envelope glycoproteins into virus particles. The first set of mutations was targeted at putative membrane-associating regions similar to those of the human immunodeficiency virus type 1 matrix protein, which include a polybasic region at the N terminus of the Mo-MuLV matrix protein and two regions predicted to form beta strands. The second set of mutations was created within hydrophobic residues to test for the production of virus particles lacking envelope proteins, with the speculation of an involvement of the membrane-spanning region of the envelope protein in incorporation into virus particles. We have found that mutation of the N-terminal polybasic region redirected virus assembly to the cytoplasm, and we show that tryptophan residues may also play a significant role in the intracellular transport of the matrix protein. In total, 21 mutants of the Mo-MuLV matrix protein were produced, but we did not observe any mutant virus particles lacking the envelope glycoproteins, suggesting that a direct interaction between the Mo-MuLV matrix protein and envelope proteins either may not exist or may occur through multiple redundant interactions. | lld:pubmed |
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| pubmed-article:9188629 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9188629 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9188629 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9188629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9188629 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9188629 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9188629 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9188629 | pubmed:author | pubmed-author:KingsmanA JAJ | lld:pubmed |
| pubmed-article:9188629 | pubmed:author | pubmed-author:KingsmanS MSM | lld:pubmed |
| pubmed-article:9188629 | pubmed:author | pubmed-author:SoneokaYY | lld:pubmed |
| pubmed-article:9188629 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9188629 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:9188629 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9188629 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9188629 | pubmed:pagination | 5549-59 | lld:pubmed |
| pubmed-article:9188629 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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