| pubmed-article:9186484 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9186484 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:9186484 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:9186484 | lifeskim:mentions | umls-concept:C0023775 | lld:lifeskim |
| pubmed-article:9186484 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9186484 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:9186484 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9186484 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9186484 | pubmed:dateCreated | 1997-7-10 | lld:pubmed |
| pubmed-article:9186484 | pubmed:abstractText | To develop a novel potent radical-scavenging antioxidant, the ideal structure of a phenolic compound was designed considering the factors that determine antioxidant potency. 2,3-Dihydro-5-hydroxy-2,2-dipentyl-4, 6-di-tert-butylbenzofuran (BO-653) was thus synthesized and its antioxidant activity was evaluated against lipid peroxidations in vitro. The electron spin resonance study showed that the phenoxyl radical derived from BO-653 was more stable than alpha-tocopheroxyl radical. BO-653 reduced alpha-tocopheroxyl radical rapidly, but alpha-tocopherol did not reduce the phenoxyl radical derived from BO-653. However, the chemical reactivity of BO-653 toward peroxyl radical was smaller than that of alpha-tocopherol. This was interpreted as the steric effect of bulky tert-butyl groups at both ortho positions which hindered the access of peroxyl radical to the phenolic hydrogen. However, the tertbutyl substituents increased the stability of BO-653 radical and also lipophilicity, and its antioxidant potency against lipid peroxidation in phosphatidylcholine liposomal membranes was superior to that of alpha-tocopherol. Ascorbic acid reduced the phenoxyl radical derived from BO-653 and spared BO-653 during the oxidation of lipid in the homogeneous solution. On the other hand, ascorbic acid did not spare BO-653 in the oxidation of liposomal membranes. It was concluded that BO-653 is a potent novel radical-scavenging antioxidant. | lld:pubmed |
| pubmed-article:9186484 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9186484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9186484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9186484 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9186484 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:KatoYY | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:TakahashiMM | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:NoguchiNN | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:KodamaTT | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:TamuraKK | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:IwakiYY | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:KomuroEE | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:NikiEE | lld:pubmed |
| pubmed-article:9186484 | pubmed:author | pubmed-author:CynshiOO | lld:pubmed |
| pubmed-article:9186484 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9186484 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9186484 | pubmed:volume | 342 | lld:pubmed |
| pubmed-article:9186484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9186484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9186484 | pubmed:pagination | 236-43 | lld:pubmed |
| pubmed-article:9186484 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9186484 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9186484 | pubmed:articleTitle | 2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: design and evaluation as a novel radical-scavenging antioxidant against lipid peroxidation. | lld:pubmed |
| pubmed-article:9186484 | pubmed:affiliation | Research Center for Advanced Science and Technology, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:9186484 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9186484 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9186484 | lld:pubmed |
