| pubmed-article:9184408 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9184408 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9184408 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9184408 | lifeskim:mentions | umls-concept:C0033382 | lld:lifeskim |
| pubmed-article:9184408 | lifeskim:mentions | umls-concept:C0085833 | lld:lifeskim |
| pubmed-article:9184408 | lifeskim:mentions | umls-concept:C0064417 | lld:lifeskim |
| pubmed-article:9184408 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:9184408 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:9184408 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:9184408 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9184408 | pubmed:dateCreated | 1997-8-18 | lld:pubmed |
| pubmed-article:9184408 | pubmed:abstractText | Elevated plasma levels of lipoprotein(a) [Lp(a)] represent a significant independent risk factor for the development of atherosclerosis. Interindividual levels of apo(a) vary over 1000-fold and are mainly due to inheritance that is linked to the locus of the apolipoprotein(a) [apo(a)] gene. The apo(a) gene encodes multiple repeats of a sequence exhibiting up to 85% DNA sequence homology with plasminogen kringle IV (K.IV), a lysine binding domain. In our search for sequence polymorphisms in the K.IV coding domain, we identified a polymorphism predicting a Thr-->Pro substitution located at amino acid position 12 of kringle IV type 8 of apo(a). The functional and clinical significance of this polymorphism was analysed in a case-control study and by comparing the in vitro lysine binding characteristics of the two Lp(a) subtypes. The case-control study (involving 153 subjects having symptomatic atherosclerosis and 153 age and gender matched normolipidemic controls) revealed a overall allele frequency for the Thr12-->Pro substitution in kringle IV type 8 of 14% and a negative association between presence of the Pro12-subtype and symptomatic atherosclerosis (p < 0.03). The in vitro lysine binding studies, using Lp(a) isolated from subjects homozygous for either Thr12 or Pro12 in K.IV type 8, revealed comparable lysine-Sepharose binding fractions for the two subtypes. The binding affinity (Kd) for immobilised plasmin degraded des-AA-fibrin (Desafib-X) was also comparable for the two subtypes, however a decreased maximal attainable binding (Bmax) for immobilised desafib-X was observed for the Pro12-subtype Lp(a). | lld:pubmed |
| pubmed-article:9184408 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9184408 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9184408 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9184408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9184408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9184408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9184408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9184408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9184408 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9184408 | pubmed:month | May | lld:pubmed |
| pubmed-article:9184408 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:9184408 | pubmed:author | pubmed-author:BoumaB NBN | lld:pubmed |
| pubmed-article:9184408 | pubmed:author | pubmed-author:van RijnH JHJ | lld:pubmed |
| pubmed-article:9184408 | pubmed:author | pubmed-author:PrinzUU | lld:pubmed |
| pubmed-article:9184408 | pubmed:author | pubmed-author:KasteleinJ... | lld:pubmed |
| pubmed-article:9184408 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:9184408 | pubmed:author | pubmed-author:LeusF RFR | lld:pubmed |
| pubmed-article:9184408 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9184408 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:9184408 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9184408 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9184408 | pubmed:pagination | 949-54 | lld:pubmed |
| pubmed-article:9184408 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:9184408 | pubmed:meshHeading | pubmed-meshheading:9184408-... | lld:pubmed |
| pubmed-article:9184408 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9184408 | pubmed:articleTitle | The identification and significance of a Thr-->Pro polymorphism in kringle IV type 8 of apolipoprotein(a). | lld:pubmed |
| pubmed-article:9184408 | pubmed:affiliation | Department of Clinical Chemistry, University Hospital Utrecht, The Netherlands. j.prins@lab.azu.nl | lld:pubmed |
| pubmed-article:9184408 | pubmed:publicationType | Journal Article | lld:pubmed |
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